CE164 Blocking Peptide | CEP164 blocking peptide

CE164 Antibody (N-term) Blocking peptide

• Gene Names: CEP164; NPHP15
• Synonyms: CE164; CE164 Antibody (N-term) Blocking peptide; Centrosomal protein of 164 kDa; Cep164; CEP164; KIAA1052; NPHP15; CEP164 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1460

• Cellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note: Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation. Persisted at centrioles throughout mitosis. Expressed in chromatin-enriched nuclear fraction of HeLa cells. In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1
• Tissue Location: Expressed in several cell lines.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CEP164 blocking peptide

Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.

NCBI and Uniprot Product Information

• NCBI GI #: 162416241
• NCBI GeneID: 22897
• UniProt Accession #: Q9UPV0; Q6PKH9; Q7Z2X9; Q9NVS0; Q9UFJ6
• Molecular Weight: 163,544 Da
• NCBI Official Full Name: Centrosomal protein of 164 kDa
• NCBI Official Synonym Full Names: centrosomal protein 164
• NCBI Official Symbol: CEP164
• NCBI Official Synonym Symbols: NPHP15
• NCBI Protein Information: centrosomal protein of 164 kDa
• UniProt Protein Name: Centrosomal protein of 164 kDa
• Protein Family: Centrosomal protein
• UniProt Gene Name: CEP164
• UniProt Synonym Gene Names: KIAA1052; NPHP15; Cep164
• UniProt Entry Name: CE164_HUMAN

NCBI Description

This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Uniprot Description

CEP164: Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. Defects in CEP164 can be a cause of nephronophthisis-related ciliopathies (NPHP-RC), a group of recessive diseases that affect kidney, retina and brain. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: centriole; centrosome; cytosol; extracellular space; nucleoplasm

Molecular Function: protein binding

Biological Process: cilium biogenesis; G2/M transition of mitotic cell cycle

Disease: Nephronophthisis 15