Cadherin-17 / LI-cadherin / CDH17 Recombinant Protein | CDH17 recombinant protein

Recombinant Human Cadherin-17 / LI-cadherin / CDH17 Protein (His tag)

Cat. Num. AAA2545803

• Gene Names: CDH17; HPT1; CDH16; HPT-1
• Purity: > 88 % as determined by SDS-PAGE
• Synonyms: Cadherin-17 / LI-cadherin / CDH17; Recombinant Human Cadherin-17 / LI-cadherin / CDH17 Protein (His tag); CDH16; FLJ26931; HPT-1; HPT1; MGC138218; MGC142024; CDH17 recombinant protein

• Host: Human Cells
• Purity/Purification: > 88 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 832

• Application Notes: The recombinant human CDH17 consists of 776 amino acids and predictes a molecular mass of 87 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh CDH17 is approximately 105-115 kDa due to glycosylation.
• Predicted N Terminal: Gln 23
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for CDH17 recombinant protein

Background: Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell type s and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for identification of adenocarcinomas of the digestive system.

Description: A DNA sequence encoding the human CDH17 (Q12864-1) extracellular domain (Met 1-Met 787) was expressed, fused with a polyhistidine tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 221316595
• NCBI GeneID: 1015
• NCBI Accession #: NP_001138135.1
• NCBI GenBank Nucleotide #: NM_001144663.1
• UniProt Accession #: Q12864; Q15336; Q2M2E0
• Molecular Weight: 92,219 Da
• NCBI Official Full Name: cadherin-17
• NCBI Official Synonym Full Names: cadherin 17
• NCBI Official Symbol: CDH17
• NCBI Official Synonym Symbols: HPT1; CDH16; HPT-1
• NCBI Protein Information: cadherin-17
• UniProt Protein Name: Cadherin-17
• Protein Family: Cadherin
• UniProt Gene Name: CDH17
• UniProt Synonym Gene Names: LI-cadherin

NCBI Description

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Uniprot Description

CDH17: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: basolateral plasma membrane; plasma membrane

Molecular Function: integrin binding; proton-dependent oligopeptide secondary active transmembrane transporter activity; transporter activity

Biological Process: calcium-dependent cell-cell adhesion; cell adhesion; cell surface receptor linked signal transduction leading to integrin activation; homophilic cell adhesion; integrin-mediated signaling pathway; oligopeptide transport