Structure
NSC-109555 ditosylate, Inhibitor
NSC-109555 ditosylate
Purity
>98% (HPLC)
Synonyms
NSC-109555 ditosylate; DDUG; NSC109555; NSC 109555; inhibitor
Purity/Purification
>98% (HPLC)
Target
Chk
Receptor
Chk
Chemical Name
4, 4'-diacetyldiphenylurea bis(guanylhydrazone) ditosylate
SMILES
O=C(NC1=CC=C(/C(C)=N/N=C(N)/N)C=C1)NC2=CC=C(/C(C)=N/N=C(N)/N)C=C2.OS(=O)(C3=CC=C(C)C=C3)=O.OS(=O)(C4=CC=C(C)C=C4)=O
Molecular Formula
C19H24N10O.2C7H8O3S
CAS Number
66748-43-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for NSC-109555 ditosylate, inhibitor
A potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2uM; displays no effect on a range of other kinases including Chk1 (IC50>10uM); inhibits histone H1 phosphorylation (IC50=0.24uM) and attenuates mitochondrial ATP synthesis; exhibits antiproliferative activity in a number of leukemias in vivo.
Product Categories/Family for NSC-109555 ditosylate, inhibitor
References
1. Jobson AG, et al. Mol Pharmacol. 2007 Oct; 72 (4):876-84.
2. Gogineni VR, et al. Cancer Lett. 2011 Dec 26; 313 (1):64-75.
3. Mikles-Robertson F, et al. Cancer Res. 1980 Apr; 40 (4):1054-61.
2. Gogineni VR, et al. Cancer Lett. 2011 Dec 26; 313 (1):64-75.
3. Mikles-Robertson F, et al. Cancer Res. 1980 Apr; 40 (4):1054-61.
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Product Notes
The NSC-109555 ditosylate (Catalog #AAA3605547) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NSC-109555 ditosylate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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