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Immunohistochemistry (IHC) (Cadherin-17 [IHC520] on Colon)

Mouse anti-Human Cadherin-17 Monoclonal Antibody | anti-CDH17 antibody

Cadherin-17

Gene Names
CDH17; HPT1; CDH16; HPT-1
Reactivity
Human
Synonyms
Cadherin-17; Monoclonal Antibody; anti-CDH17 antibody
Ordering
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Sequence Length
832
Application Notes
The recommended working dilution range is 1:100-1:200
Positive Control
Colorectal Carcinoma

Immunohistochemistry (IHC)

(Cadherin-17 [IHC520] on Colon)

Immunohistochemistry (IHC) (Cadherin-17 [IHC520] on Colon)
Related Product Information for anti-CDH17 antibody
Cadherin-17 is a transmembrane glycoprotein. Anti-Cadherin-17 can be used to stain normal colonic, appendicular, and small intestinal epithelia. The antibody produces diffuse staining in colorectal adenocarcinoma, and focal or scattered staining in adenocarcinomas of the pancreas, bile duct, or stomach.
References
1. Su M, et al. Mod Pathol. 2008; 21:1379-1386.
2. Gessner R, et al. Ann N Y Acad Sci. 2000; 915:136-143.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
92,219 Da
NCBI Official Full Name
cadherin-17
NCBI Official Synonym Full Names
cadherin 17
NCBI Official Symbol
CDH17
NCBI Official Synonym Symbols
HPT1; CDH16; HPT-1
NCBI Protein Information
cadherin-17
UniProt Protein Name
Cadherin-17
Protein Family
UniProt Gene Name
CDH17
UniProt Synonym Gene Names
LI-cadherin

NCBI Description

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Uniprot Description

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.

Research Articles on CDH17

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Product Notes

The CDH17 cdh17 (Catalog #AAA344042) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Cadherin-17 reacts with Human and may cross-react with other species as described in the data sheet. The recommended working dilution range is 1:100-1:200. Researchers should empirically determine the suitability of the CDH17 cdh17 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cadherin-17, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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