BAG family molecular chaperone regulator 3 Recombinant Protein | Bag3 recombinant protein

Recombinant Mouse BAG family molecular chaperone regulator 3

Cat. Num. AAA1416845

• Gene Names: Bag3; Bis; mg638; AA407278
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: BAG family molecular chaperone regulator 3; Recombinant Mouse BAG family molecular chaperone regulator 3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Bag3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-577aa; Full Length of Mature Protein
• Sequence: SAATQSPMMQMASGNGASDRDPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVPPEGPKDTASSANGPSRDGSRLLPIREGHPIYPQLRPGYIPIPVLHEGSENRQPHLFHAYSQPGVQRFRTEAAAATPQRSQSPLRGGMTEAAQTDKQCGQMPATATTAAAQPPTAHGPERSQSPAASDCSSSSSSASLPSSGRSSLGSHQLPRGYIPIPVIHEQNITRPAAQPSFHQAQKTHYPAQQGEYQPQQPVYHKIQGDDWEPRPLRAASPFRSPVRGASSREGSPARSGTPVHCPSPIRVHTVVDRPQPMTHREPPPVTQPENKPESKPGPAGPDLPPGHIPIQVIRREADSKPVSQKSPPPAEKVEVKVSSAPIPCPSPSPAPSAVPSPPKNVAAEQKAAPSPAPAEPAAPKSGEAETPPKHPGVLKVEAILEKVQGLEQAVDSFEGKKTDKKYLMIEEYLTKELLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKAIDVPGQVQVYELQPSNLEAEQPLQEIMGAVVADKDKKGPENKDPQTESQQLEAKAATPPNPSNPADSAGNLVAP
• Sequence Length: 577

• Production Note: Special Offer: The Yeast host-expressed protein is manufactured from a stock plasmid containing the protein gene. Yeasthost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The Yeast host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select Yeast host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to [email protected] for more details.
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for Bag3 recombinant protein

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.

References

Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.Lee J.H., Takahashi T., Yasuhara N., Inazawa J., Kamada S., Tsujimoto Y.Oncogene 18:6183-6190(1999) Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method.Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.Large-scale phosphorylation analysis of mouse liver.Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) Solution structure of the murine BAG domain of Bcl2-associated athanogene 3.RIKEN structural genomics initiative (RSGI) Submitted (FEB-2004) to the PDB data bank

NCBI and Uniprot Product Information

• NCBI GI #: 115270960
• NCBI GeneID: 29810
• NCBI Accession #: NP_038891.4
• NCBI GenBank Nucleotide #: NM_013863.5
• UniProt Accession #: Q9JLV1; Q9CQL3; Q9JJC7
• Molecular Weight: 63.7 kDa
• NCBI Official Full Name: BAG family molecular chaperone regulator 3
• NCBI Official Synonym Full Names: BCL2-associated athanogene 3
• NCBI Official Symbol: Bag3
• NCBI Official Synonym Symbols: Bis; mg638; AA407278
• NCBI Protein Information: BAG family molecular chaperone regulator 3
• UniProt Protein Name: BAG family molecular chaperone regulator 3
• Protein Family: BAG family molecular chaperone regulator
• UniProt Gene Name: Bag3
• UniProt Synonym Gene Names: Bis; BAG-3
• UniProt Entry Name: BAG3_MOUSE

Uniprot Description

BAG3: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity. Defects in BAG3 are the cause of myopathy myofibrillar type 6 (MFM6). A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material. Defects in BAG3 are the cause of cardiomyopathy dilated type 1HH (CMD1HH). CMD1HH is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Protein type: Apoptosis

Cellular Component: cytoplasm; cytosol; neuron projection; plasma membrane; Z disc

Molecular Function: adenyl-nucleotide exchange factor activity; chaperone binding; protein binding; protein complex binding

Biological Process: apoptosis; induction of apoptosis via death domain receptors; protein stabilization; regulation of catalytic activity