Immunoprecipitation (IP)
(Immunoprecipitating Bag3 in K562 whole cell lysate Lane 1: Rabbit control IgG (1ug)instead of MBS1495442 in K562 whole cell lysate. For western blotting,a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)Lane 2: MBS1495442 (6ug)+ K562 whole cell lysate (500ug)Lane 3: K562 whole cell lysate (10ug))
Rabbit anti-Mouse BAG family molecular chaperone regulator 3 Polyclonal Antibody | anti-BAG antibody
Rabbit anti-mouse BAG family molecular chaperone regulator 3 polyclonal Antibody
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunoprecipitation (IP)
(Immunoprecipitating Bag3 in K562 whole cell lysate Lane 1: Rabbit control IgG (1ug)instead of MBS1495442 in K562 whole cell lysate. For western blotting,a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)Lane 2: MBS1495442 (6ug)+ K562 whole cell lysate (500ug)Lane 3: K562 whole cell lysate (10ug))
Immunoprecipitation (IP)
(Immunoprecipitating Bag3 in K562 whole cell lysate Lane 1: Rabbit control IgG (1ug)instead of MBS1495442 in K562 whole cell lysate. For western blotting,a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)Lane 2: MBS1495442 (6ug)+ K562 whole cell lysate (500ug)Lane 3: K562 whole cell lysate (10ug))
NCBI and Uniprot Product Information
Uniprot Description
BAG3: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity. Defects in BAG3 are the cause of myopathy myofibrillar type 6 (MFM6). A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material. Defects in BAG3 are the cause of cardiomyopathy dilated type 1HH (CMD1HH). CMD1HH is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Protein type: Apoptosis
Cellular Component: cytoplasm; cytosol; neuron projection; plasma membrane; Z disc
Molecular Function: adenyl-nucleotide exchange factor activity; chaperone binding; protein binding; protein complex binding
Biological Process: apoptosis; induction of apoptosis via death domain receptors; protein stabilization; regulation of catalytic activity
Research Articles on BAG
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Product Notes
The BAG bag3 (Catalog #AAA1495442) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-mouse BAG family molecular chaperone regulator 3 polyclonal Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's BAG family molecular chaperone regulator 3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the BAG bag3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BAG family molecular chaperone regulator 3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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