Testing Data
HDAC-5 Assay Kit
HDAC-5 Inhibitor Screening Kit (Fluorometric)
Synonyms
HDAC-5; HDAC-5 Inhibitor Screening Kit (Fluorometric); HDAC-5 assay kit
Detection Method
Fluorescence: Ex/Em 380/460nm
Features & Benefits
Useful for the identification of potential HDAC-5 inhibitors
Simple and reliable test to screen/study/characterize HDAC5 inhibitors
High-throughput compatible
Includes Inhibitor Control (Trichostatin A)
Screening potential inhibitors of Histone Deacetylase 5
Characterizing/studying HDAC5 inhibitors in plasma samples
Simple and reliable test to screen/study/characterize HDAC5 inhibitors
High-throughput compatible
Includes Inhibitor Control (Trichostatin A)
Screening potential inhibitors of Histone Deacetylase 5
Characterizing/studying HDAC5 inhibitors in plasma samples
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store at -80 degree C
Shipping: Dry Ice
Shelf life: ~12 months
Shipping: Dry Ice
Shelf life: ~12 months
Testing Data
Testing Data
Testing Data
Testing Data
Related Product Information for HDAC-5 assay kit
Histone Deacetylase 5 or HDAC-5 belongs to Class II Histone deacetylase family. It represses transcription by deacetylating lysine residues on the N-terminal part of histones H2A, H2B, H3 and H4. This epigenetic repression caused by HDAC-5, plays a role in transcriptional regulation, cell cycle progression and development. It interacts with myocyte enhancing factor (MEF-2) proteins that are associated with colon cancer, causing the repression of MEF-2 dependent gene expression. HDAC-5 is also involved in epigenetic regulation of ESR1 expression in breast cancer. HDAC-5 inhibition induces reactive oxygen species (ROS) production, ultimately leading to apoptotic cell death as well as mechanisms of mitochondrial quality control processes such as mitophagy and mitobiogenesis. Therefore, HDAC-5 inhibition in cancer cells significantly reduces tumor size due to apoptotic cell death of cancer cells (Hendrick, et al, Oncogene. 2017 Aug 24; 36 (34) :4859-4874), which makes HDAC-5 an attractive target for anti-cancer therapy. HDAC-5 Inhibitor Screening Kit is a plate-based fluorometric kit for screening potential HDAC-5 inhibitors. The principle of the kit is based on the deacetylation of an acetylated substrate by HDAC-5. The deacetylated product is then cleaved by a developer to release a highly fluorescent moiety with Ex/Em= 380/460 nm. Trichostatin A, a well-known HDAC inhibitor is provided as inhibitor control.
Product Categories/Family for HDAC-5 assay kit
Similar Products
Product Notes
The HDAC-5 (Catalog #AAA849561) is an Assay Kit and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HDAC-5, Assay Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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