Western Blot (WB)
(Western blot analysis of extracts from Human kidney, using SLFN14 Antibody. The lane on the left was treated with blocking peptide.)
Rabbit SLFN14 Polyclonal Antibody | anti-SLFN14 antibody
SLFN14 Antibody
Gene Names
SLFN14; BDPLT20
Reactivity
HumanPredicted Reactivity: Horse(100%), Rabbit(100%)
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
SLFN14; Polyclonal Antibody; SLFN14 Antibody; Schlafen family member 14; SLN14_HUMAN; anti-SLFN14 antibody
Host
Rabbit
Reactivity
Human
Predicted Reactivity: Horse(100%), Rabbit(100%)
Predicted Reactivity: Horse(100%), Rabbit(100%)
Clonality
Polyclonal
Isotype
IgG
Specificity
SLFN14 Antibody detects endogenous levels of total SLFN14.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1mg/ml (varies by lot)
Sequence Length
912
Applicable Applications for anti-SLFN14 antibody
ELISA (EIA)
Application Notes
WB: 1:500-1:2000
ELISA(peptide): 1:20,000-1:40,000
ELISA(peptide): 1:20,000-1:40,000
Immunogen
A synthesized peptide derived from human SLFN14, corresponding to a region within C-terminal amino acids.
Fragment
Fab fragment
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of extracts from Human kidney, using SLFN14 Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from Human kidney, using SLFN14 Antibody. The lane on the left was treated with blocking peptide.)
Related Product Information for anti-SLFN14 antibody
Function: Shows no ribosome-associated and endoribonuclease activities.Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.
Subcellular Location: Nucleus.
Tissue Specificity: Expressed in megakaryocytes and platelets (at protein level) (PubMed:26280575). Weakly expressed in melanocytes and malignant melanoma cells (PubMed:20956525).
Subunit Structure: Associates with ribosomes in an ATP-independent manner (PubMed:25996083).
Similarity: Belongs to the Schlafen family. Subgroup III subfamily.
Subcellular Location: Nucleus.
Tissue Specificity: Expressed in megakaryocytes and platelets (at protein level) (PubMed:26280575). Weakly expressed in melanocytes and malignant melanoma cells (PubMed:20956525).
Subunit Structure: Associates with ribosomes in an ATP-independent manner (PubMed:25996083).
Similarity: Belongs to the Schlafen family. Subgroup III subfamily.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Observed Molecular Weight: (Observed)103kD.
Predicted Molecular Weight: (Calculated)104kDa.
Predicted Molecular Weight: (Calculated)104kDa.
NCBI Official Full Name
protein SLFN14
NCBI Official Synonym Full Names
schlafen family member 14
NCBI Official Symbol
SLFN14
NCBI Official Synonym Symbols
BDPLT20
NCBI Protein Information
protein SLFN14
UniProt Protein Name
Schlafen family member 14
Protein Family
UniProt Gene Name
SLFN14
UniProt Entry Name
SLN14_HUMAN
NCBI Description
The protein encoded by this gene plays an important role in platelet formation and function. Defects in this gene are a cause of thrombocytopenia with excessive bleeding. [provided by RefSeq, Jul 2016]
Uniprot Description
SLFN14: Belongs to the Schlafen family. 2 isoforms of the human protein are produced by alternative splicing
Chromosomal Location of Human Ortholog: 17q12
Molecular Function: ATP binding
Research Articles on SLFN14
Similar Products
Product Notes
The SLFN14 slfn14 (Catalog #AAA9612338) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SLFN14 Antibody reacts with Human Predicted Reactivity: Horse(100%), Rabbit(100%) and may cross-react with other species as described in the data sheet. AAA Biotech's SLFN14 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). WB: 1:500-1:2000 ELISA(peptide): 1:20,000-1:40,000. Researchers should empirically determine the suitability of the SLFN14 slfn14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLFN14, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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