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Testing Data

beta-Secretase Assay Kit

Human beta-Secretase (BACE1) Inhibitor Screening Kit (Fluorometric)

Synonyms
beta-Secretase; Human beta-Secretase (BACE1) Inhibitor Screening Kit (Fluorometric); BACE1 Activity Fluorometric Assay Kit; ASP2 Activity Fluorometric Assay Kit; Memapsin-2 Activity Fluorometric Assay Kit; beta-Secretase assay kit
Ordering
For Research Use Only!
Detection Method
Fluorescence: Ex/Em 345/500nm
Features & Benefits
Highly Sensitive Assay for screening potential BACE1 inhibitors
Simple procedure; takes ~ 1 hour
Fast and convenient
The assay is sensitive, stable and high-throughput adaptable.
Preparation and Storage
Store at -20 degree C
Shelf life: ~12 months

Testing Data

Testing Data

Testing Data

Testing Data
Related Product Information for beta-Secretase assay kit
beta-Secretase (Beta-site amyloid precursor protein (APP) cleaving enzyme 1/BACE1), participates in the initial cleavage of amyloid precursor-APP generating two soluble N-terminal and C-terminal fragments. Another secretase isozyme, gamma-Secretase, cleaves C-terminal fragment producing amyloid beta. Accumulation of amyloid beta in brain results in the formation of amyloid plaques, which contribute in the development of Alzheimer's disease (AD) in humans. Therefore, screening for novel and specific inhibitors of human beta-Secretase (BACE1) has become critical in Alzheimer's Disease-related drug discovery research. In Human beta-Secretase (BACE1) Inhibitor Screening Kit, human BACE1 cleaves a quenched substrate, specific for BACE1, generating a product with high fluorescence that can be measured at Ex/Em= 435/500 nm. In the presence of BACE1 Inhibitor (control included in this kit), the enzymatic cleavage is impeded and could be used to screen for new inhibitor compounds. The assay is high-throughput adaptable and can be completed in less than 1 hr
Product Categories/Family for beta-Secretase assay kit

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Product Notes

The beta-Secretase (Catalog #AAA849748) is an Assay Kit and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "beta-Secretase, Assay Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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