Mouse anti-Human TEM7 Monoclonal Antibody | anti-PLXDC1 antibody
TEM7 (Tumor Endothelial Marker 7, Plexin Domain Containing 1, Plexin Domain-containing Protein 1 Precursor, PLXDC1, Tumor Endothelial Marker 3, TEM3)
Gene Names
PLXDC1; TEM3; TEM7; FLJ36270; FLJ45632; DKFZp686F0937; PLXDC1
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
TEM7; Monoclonal Antibody; TEM7 (Tumor Endothelial Marker 7; Plexin Domain Containing 1; Plexin Domain-containing Protein 1 Precursor; PLXDC1; Tumor Endothelial Marker 3; TEM3); Anti -TEM7 (Tumor Endothelial Marker 7; anti-PLXDC1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
9F189
Specificity
Species Crossreactivity: Human
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
PBS containing 0.2% gelatin, 0.05% sodium azide.
Applicable Applications for anti-PLXDC1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Suitable for use in Western Blot and Immunohistochemistry.
Immunogen
This monoclonal antibody was developed by immunizing mice with a synthetic petide containing amino acids 411-427 of human TEM7.
Positive Control
HCT-116
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 3 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-PLXDC1 antibody
Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.
Product Categories/Family for anti-PLXDC1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
39,639 Da
NCBI Official Full Name
tumor endothelial marker 7-intracellular
NCBI Official Synonym Full Names
plexin domain containing 1
NCBI Official Symbol
PLXDC1
NCBI Official Synonym Symbols
TEM3; TEM7; FLJ36270; FLJ45632; DKFZp686F0937; PLXDC1
NCBI Protein Information
plexin domain-containing protein 1; 2410003I07Rik; tumor endothelial marker 3; tumor endothelial marker 7
UniProt Protein Name
cDNA FLJ45632 fis, clone CHONS2001834, highly similar to Homo sapiens tumor endothelial marker 7 (TEM7)
Protein Family
UniProt Entry Name
Q6ZSC8_HUMAN
Uniprot Description
PLXDC1: Plays a critical role in endothelial cell capillary morphogenesis. Belongs to the plexin family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q21.1
Cellular Component: extracellular space; tight junction; cell soma; dendrite; cytoplasm; integral to membrane; extracellular region; plasma membrane; intracellular; receptor complex
Molecular Function: protein binding; receptor activity
Biological Process: spinal cord development; angiogenesis
Research Articles on PLXDC1
1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
2. All osteosarcoma cell lines, 6/9 tumors but none of the bone specimens expressed mRNA of TEM7 secreted forms 1 and 2.
3. TEM7 may play significant role in proliferation and maintenance of neovascular endothelial cells in fibrovascular membranes. TEM7 may be molecular target for new diagnostic and therapeutic strategies for proliferative diabetic retinopathy.
4. TEM7 expression level closely parallels histology-based prognostication of OGS metastasis and, therefore, it is a therapeutic target.
2. All osteosarcoma cell lines, 6/9 tumors but none of the bone specimens expressed mRNA of TEM7 secreted forms 1 and 2.
3. TEM7 may play significant role in proliferation and maintenance of neovascular endothelial cells in fibrovascular membranes. TEM7 may be molecular target for new diagnostic and therapeutic strategies for proliferative diabetic retinopathy.
4. TEM7 expression level closely parallels histology-based prognostication of OGS metastasis and, therefore, it is a therapeutic target.
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Product Notes
The PLXDC1 (Catalog #AAA607385) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TEM7 (Tumor Endothelial Marker 7, Plexin Domain Containing 1, Plexin Domain-containing Protein 1 Precursor, PLXDC1, Tumor Endothelial Marker 3, TEM3) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TEM7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot and Immunohistochemistry. Researchers should empirically determine the suitability of the PLXDC1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TEM7, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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