Mouse anti-Bovine LDL Monoclonal Antibody | anti-LDL antibody
LDL Receptor antibody
NCBI and Uniprot Product Information
Uniprot Description
LRP2: Acts together with cubilin to mediate HDL endocytosis. May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release. Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS); also known as faciooculoacousticorenal syndrome (FOAR syndrome). DBS is a rare autosomal recessive disorder characterized by major malformations including agenesis of the corpus callosum, congenital diaphragmatic hernia, facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. The FOAR syndrome was first described as comprising facial anomalies, ocular anomalies, sensorineural hearing loss, and proteinuria. DBS and FOAR were first described as distinct disorders but the classic distinguishing features between the 2 disorders were presence of proteinuria and absence of diaphragmatic hernia and corpus callosum anomalies in FOAR. Early reports noted that the 2 disorders shared many phenotypic features and may be identical. Although there is variability in the expression of some features (e.g. agenesis of the corpus callosum and proteinuria), DBS and FOAR are now considered to represent the same entity. Belongs to the LDLR family.
Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral
Cellular Component: Golgi apparatus; extracellular space; protein complex; brush border membrane; endoplasmic reticulum; lysosomal membrane; integral to membrane; coated pit; lipid raft; membrane; endocytic vesicle; apical part of cell; cytoplasm; apical plasma membrane; endosome; receptor complex; brush border
Molecular Function: protein binding; lipoprotein transporter activity; hemoglobin binding; low-density lipoprotein receptor binding; metal ion binding; protein complex binding; calcium ion binding; receptor activity; SH3 domain binding; PDZ domain binding
Biological Process: hormone secretion; cell proliferation; receptor-mediated endocytosis; vitamin metabolic process; lipoprotein transport; forebrain development; hemoglobin import; endocytosis; transcytosis; endosome transport; response to X-ray
Research Articles on LDL
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Product Notes
The LDL lrp2 (Catalog #AAA530539) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The LDL Receptor antibody reacts with Bovine and may cross-react with other species as described in the data sheet. AAA Biotech's LDL can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF). IF: 1:10-1:50. Researchers should empirically determine the suitability of the LDL lrp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LDL, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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