Typical Testing Data/Standard Curve (for reference only)
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Rat Low Density Lipoprotein Receptor Related Protein 2 (LRP2) ELISA Kit | LRP2 elisa kit
Rat Low Density Lipoprotein Receptor Related Protein 2 (LRP2) ELISA Kit
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
Typical Testing Data/Standard Curve (for reference only)
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Typical Testing Data/Standard Curve (for reference only)
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Principle of the Assay: The microplate provided in this kit has been pre-coated with an antibody specific to LRP2. Standards or samples are then added to the appropriate microplate wells with a biotin-conjugated antibody specific to LRP2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain LRP2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm +/- 10nm. The concentration of LRP2 in the samples is then determined by comparing the O.D. of the samples to the standard curve.
NCBI and Uniprot Product Information
Uniprot Description
LRP2: Acts together with cubilin to mediate HDL endocytosis. May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release. Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS); also known as faciooculoacousticorenal syndrome (FOAR syndrome). DBS is a rare autosomal recessive disorder characterized by major malformations including agenesis of the corpus callosum, congenital diaphragmatic hernia, facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. The FOAR syndrome was first described as comprising facial anomalies, ocular anomalies, sensorineural hearing loss, and proteinuria. DBS and FOAR were first described as distinct disorders but the classic distinguishing features between the 2 disorders were presence of proteinuria and absence of diaphragmatic hernia and corpus callosum anomalies in FOAR. Early reports noted that the 2 disorders shared many phenotypic features and may be identical. Although there is variability in the expression of some features (e.g. agenesis of the corpus callosum and proteinuria), DBS and FOAR are now considered to represent the same entity. Belongs to the LDLR family.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 2 C2|2 40.74 cM
Cellular Component: apical part of cell; apical plasma membrane; axon; brush border; brush border membrane; clathrin-coated pit; cytoplasm; dendrite; endocytic vesicle; endoplasmic reticulum; endosome; external side of plasma membrane; extracellular space; Golgi apparatus; integral component of membrane; lysosomal membrane; membrane; membrane raft; protein complex; receptor complex
Molecular Function: calcium ion binding; chaperone binding; drug binding; hemoglobin binding; hormone binding; lipoprotein transporter activity; low-density lipoprotein receptor binding; metal ion binding; PDZ domain binding; protein binding; protein complex binding; receptor activity; SH3 domain binding; steroid hormone receptor binding
Biological Process: cell proliferation; endocytosis; endosomal transport; forebrain development; heart development; hemoglobin import; hormone secretion; lipoprotein transport; male gonad development; metal ion transport; negative regulation of BMP signaling pathway; neural tube closure; positive regulation of neurogenesis; receptor-mediated endocytosis; response to X-ray; sensory perception of sound; transcytosis; vagina development; vitamin metabolic process
Research Articles on LRP2
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Product Notes
The Rat LRP2 lrp2 (Catalog #AAA2704917) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2704917 ELISA Kit recognizes Rat LRP2. It is sometimes possible for the material contained within the vial of "Low Density Lipoprotein Receptor Related Protein 2 (LRP2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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