Rabbit ARL4C Polyclonal Antibody | anti-ARL4C antibody

ARL4C Antibody

Cat. Num. AAA9611584

• Gene Names: ARL4C; LAK; ARL7
• Reactivity: Human; Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
• Applications: Western Blot
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: ARL4C; Polyclonal Antibody; ARL4C Antibody; ADP ribosylation factor like 4C; ADP ribosylation factor like 7; ADP-ribosylation factor-like protein 4C; ADP-ribosylation factor-like protein 7; ADP-ribosylation factor-like protein LAK; Arl4c; ARL4C_HUMAN; ARL7; LAK; anti-ARL4C antibody

• Host: Rabbit
• Reactivity: Human; Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ARL4C Antibody detects endogenous levels of ARL4C.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 192

• Applicable Applications for anti-ARL4C antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthesized peptide derived from human ARL4C.
• Tissue Specificity: Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta.
• Fragment: Fab Fragment
• Conjugate: Unconjugated
• Subcellular Location: Plasma Membrane
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts from Colo205, using ARL4C Antibody. The lane on the left was treated with blocking peptide.)

Western Blot (WB)

(Western blot analysis of extracts from HUVEC cells, using ARL4C Antibody. The lane on the left was treated with blocking peptide.)

Related Product Information for anti-ARL4C antibody

Description: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.

Subunit Structure: Interacts with CYTH2. Interacts with alpha tubulin; interaction is independent on the ARL4C GTP or GDP binding status.

Similarity: Belongs to the small GTPase superfamily. Arf family.

NCBI and Uniprot Product Information

• NCBI GI #: 6552296
• NCBI GeneID: 10123
• NCBI Accession #: NP_005728.2
• NCBI GenBank Nucleotide #: NP_005728.2
• UniProt Accession #: P56559
• Molecular Weight: Observed: 21 kDa; Predicted: 22 kDa
• NCBI Official Full Name: ADP-ribosylation factor-like protein 4C isoform 2
• NCBI Official Synonym Full Names: ADP ribosylation factor like GTPase 4C
• NCBI Official Symbol: ARL4C
• NCBI Official Synonym Symbols: LAK; ARL7
• NCBI Protein Information: ADP-ribosylation factor-like protein 4C
• UniProt Protein Name: ADP-ribosylation factor-like protein 4C
• Protein Family: ADP-ribosylation factor-like protein
• UniProt Gene Name: ARL4C
• UniProt Synonym Gene Names: ARL7
• UniProt Entry Name: ARL4C_HUMAN

NCBI Description

ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in cholesterol transport. [provided by RefSeq, Jul 2008]