Molecular Structure
AICAR, inhibitor
AICAR
Purity
>98% (TLC); NMR (Conforms)
Synonyms
AICAR; ZM-447439; N-[4-[[6-Methoxy-7-[3-(4-morpholiny¬l)propoxy]-4-quinazolinyl]amino]phenyl]benzamide; inhibitor
Purity/Purification
>98% (TLC); NMR (Conforms)
Form/Format
Off white solid
CAS Number
2627-69-2
Molecular Formula
C9H14N4O5
Melting Point
213-214 degree C
Activity
Aurora B kinase inhibitor
Reconstitution
May be dissolved in DMSO (50 mg/ml)
Solubilization
Soluble in DMSO (15 mg/ml); or water (15 mg/ml)
Preparation and Storage
Store desiccated as supplied at -20 degree C for up to 2 years. Store solutions at -20 degree C for up to 3 months.
Molecular Structure
Molecular Structure
Related Product Information for AICAR, inhibitor
AMPK activator
Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 uM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells.
Scientific Background: Activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor (1). Promotes skeletal muscle autophagy via activation of FoxO3a (2). Controls smooth muscle cell hyperproliferation in vascular disease (3). Cell permeable.
Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 uM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells.
Scientific Background: Activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor (1). Promotes skeletal muscle autophagy via activation of FoxO3a (2). Controls smooth muscle cell hyperproliferation in vascular disease (3). Cell permeable.
Product Categories/Family for AICAR, inhibitor
References
1. C Ditchfield et al J. Cell Biol. 2003 161:267 2. F Girdler et al J. Cell Sci. 2006 119:3664 3. F H Jung et al J. Med. Chem. 2006 49:955
Similar Products
Product Notes
The AICAR (Catalog #AAA515046) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AICAR, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
