Structure
REDX-05358, Inhibitor
REDX-05358
Purity
>98% (HPLC)
Synonyms
REDX-05358; REDX 05358; REDX05358; inhibitor
Purity/Purification
>98% (HPLC)
Target
Raf
Receptor
Raf
Chemical Name
5-[[3-[5-(2-Chlorophenyl)-1H-imidazol-2-yl]chroman-6-yl]oxy]-3, 4-dihydro-1H-1, 8-naphthyridin-2-one
SMILES
O=C(CC1)NC2=C1C(OC3=CC(CC(C4=NC=C(C5=CC=CC=C5Cl)N4)CO6)=C6C=C3)=CC=N2
Molecular Formula
C26H21ClN4O3
CAS Number
1884226-20-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for REDX-05358, inhibitor
REDX-05358 is a novel potent, highly selective, orally bioavailable pan RAF inhibitor with IC50 of 0.1, 0.68, 0.171, and 0.076nM for ARAF, BRAF, BRAF (V600E), and CRAF, respectively; denmonstrates high selectivity profile against a panel of 468 kinases, exhibits negligible paradoxical activation due to inhibition of both RAF monomers and dimers; not only inhibits MAPK signalling in BRAF V600E mutant tumor cells, but also in those harbouring NRAS and KRAS mutations; exhibits in vivo efficacy in BRAF V600E CRC xenograft model.
Product Categories/Family for REDX-05358, inhibitor
References
1. Helen Mason, et al. AACR, Abstract 5160.
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Product Notes
The REDX-05358 (Catalog #AAA3602942) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "REDX-05358, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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