Structure
Vemurafenib, Inhibitor
Vemurafenib
Purity
>98% (HPLC)
Synonyms
Vemurafenib; PLX-4032; RG7204; RO5185426; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 6.2mg/mL
Target
Raf
Receptor
ACK1; BLK; B-Raf; B-Raf (V600E); BRK; C-Raf; CSK; FGR; FRK (PTK5); Lck; LynB; MAP4K5 (KHS1); MNK2; NEK11; Src; SRMS; WNK3; Yes1; c-Raf-1
Chemical Name
1-Propanesulfonamide, N-[3-[[5-(4-chlorophenyl)-1H-pyrrolo[2, 3-b]pyridin-3-yl]carbonyl]-2, 4-difluorophenyl]
SMILES
CCCS(=O)(NC1=CC=C(F)C(C(C2=CNC3=NC=C(C4=CC=C(Cl)C=C4)C=C32)=O)=C1F)=O
Molecular Formula
C23H18ClF2N3O3S
CAS Number
918504-65-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Vemurafenib, inhibitor
Vemurafenib (PLX-4032; RG7204; RO5185426) is a potent, selective B-RAF V600E inhibitor with IC50 of 30nM, displays similar potency for c-RAF-1 (IC50=48nM), and has selectivity against many other kinases, including wild type B-RAF (IC50=100nM); potently inhibits proliferation of a panel of tumor cell lines, selectively blocks the RAF/MEK/ERK pathway in BRAF mutant cells; causes tumor regressions and improves animal survival in tumor xenograft models of BRAF (V600E)-expressing melanoma. Skin Cancer Approved
Product Categories/Family for Vemurafenib, inhibitor
References
1. Bollag G, et al. Nature. 2010 Sep 30; 467 (7315):596-9.
2. Joseph EW, et al. Proc Natl Acad Sci U S A. 2010 Aug 17; 107 (33):14903-8.
3. Yang H, et al. Cancer Res. 2010 Jul 1; 70 (13):5518-27.
4. Sndergaard JN, et al. J Transl Med. 2010 Apr 20; 8:39.
2. Joseph EW, et al. Proc Natl Acad Sci U S A. 2010 Aug 17; 107 (33):14903-8.
3. Yang H, et al. Cancer Res. 2010 Jul 1; 70 (13):5518-27.
4. Sndergaard JN, et al. J Transl Med. 2010 Apr 20; 8:39.
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Product Notes
The Vemurafenib (Catalog #AAA3606587) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Vemurafenib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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