Structure
AZ304, Inhibitor
AZ304
Purity
>98% (HPLC)
Synonyms
AZ304; AZ 304; AZ-304; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 85mg/mL
Ethanol: 4mg/mL
Water: Insoluble (<1mg/mL refers to the product slightly soluble or insoluble)
Ethanol: 4mg/mL
Water: Insoluble (<1mg/mL refers to the product slightly soluble or insoluble)
Target
Raf
Receptor
B-RAFV600E; B-RAF; C-RAF; p38; CSF1R
Chemical Name
3-(2-cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide
SMILES
O=C(NC1=CC=C(C)C(NC2=C3C=CC(OC)=CC3=NC=N2)=C1)C4=CC=CC(C(C)(C#N)C)=C4
Molecular Formula
C27H25N5O2
CAS Number
942507-42-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AZ304, inhibitor
AZ304 is a novel potent, dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF and wild type CRAF with IC50 of 79nM, 38nM and 68nM, respectively; also potentlt inhibits p38 and CSF1R with IC50 of 6 and 35nM, has no activity for MAP3K7, CSK, IGF1R, EGFR, FGFR, CDK2, CDK4, JAK2, SRC (IC50>5uM); potently reduces p-ERK with mean EC50 of 65nM in the V600E mutant BRAF containing melanoma cell line A375, EC50 of 60nM in wild type BRAF melanoma cell line SK-MEL-31; inhibits cell proliferation in mutant BRAF, wt BRAF/RAS and mutant RAS with IC50 of 0.08-7.72uM, 0.43-11.7uM 0.9-16.66uM, respectively; Cetuximab enhances the potency of AZ304 independently of BRAF mutational status in vivo.
Product Categories/Family for AZ304, inhibitor
References
1. Ma R, et al. Br J Cancer. 2018 May 14. doi: 10.1038/s41416-018-0086-x.
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Product Notes
The AZ304 (Catalog #AAA3606740) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AZ304, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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