Structure
BGB-283 Biochemical
BGB-283
Purity
>98% (HPLC)
Synonyms
BGB-283; Lifirafenib; BGB 283; BGB283; BGB-283 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=125mg/mL
Target
Raf
Receptor
Raf
Chemical Name
1, 8-Naphthyridin-2(1H)-one, 5-[[(1R, 1aS, 6bR)-1a, 6b-dihydro-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1H-cyclopropa[b]benzofuran-5-yl]oxy]-3, 4-dihydro-, rel
SMILES
[H][C@@]1(C2=CC(OC3=C(CCC4=O)C(N4)=NC=C3)=CC=C2O[C@]51[H])[C@@H]5C6=NC7=CC=C(C=C7N6)C(F)(F)F
Molecular Formula
C25H17F3N4O3
CAS Number
1446090-77-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BGB-283 biochemical
BGB-283 (Lifirafenib, BGB283) is a potent pan RAF inhibitor of BRAF V600E, wt BRAF, CRAFY340/341D and wt ARAF (IC50=5-40nM); inhibits recombinant BRAFV600E with IC50 of 23nM; also inhibits EGFR and EGFR T790M/L858R with IC50 of 29nM and 495nM respectively; potently inhibits BRAF (V600E)-activated ERK phosphorylation and cell proliferation in vitro; shows tumor growth inhibition in both cell line-derived and primary human colorectal tumor xenografts bearing BRAF (V600E) mutation. Colon Cancer Preclinical
Product Categories/Family for BGB-283 biochemical
References
1. Tang Z, et al. Mol Cancer Ther. 2015 Oct; 14 (10):2187-97.
2. Cancer Discov. 2016 Jul; 6 (7):OF1.
2. Cancer Discov. 2016 Jul; 6 (7):OF1.
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Product Notes
The BGB-283 (Catalog #AAA3601891) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BGB-283, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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