Structure
Belvarafenib, Inhibitor
Belvarafenib
Purity
>98% (HPLC)
Synonyms
Belvarafenib; HM95573; GDC5573; inhibitor
Purity/Purification
>98% (HPLC)
Target
Raf
Receptor
Raf
Chemical Name
4-amino-N-[1-(3-chloro-2-fluoroanilino)-6-methylisoquinolin-5-yl]thieno[3, 2-d]pyrimidine-7-carboxamide
SMILES
FC1=C(Cl)C=CC=C1NC2=NC=CC3C(NC(C4=CSC5=C4N=CN=C5N)=O)=CC(C)=CC23
Molecular Formula
C23H16ClFN6OS
CAS Number
1446113-23-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Belvarafenib, inhibitor
Belvarafenib (HM95573, GDC5573) is a novel potent, selective RAF inhibitor with IC50 of 41nM, 7nM and 2nM forBRAF WT, BRAF V600E and CRAF, respectively; inhibits cell proliferation of A375 (BRAF V600E) and SK-MEL-30 (NRAS Q61K) with IC50 of 57 and 24nM, also inhibits the phosphorylations of MEK and ERK downstream kinases in mutant BRAF and mutant NRAS melanoma cells; shows the excellent antitumor activity in mouse models xenografted with both of BRAF mutation cell lines (e. G. A375 and SK-MEL-28) and NRAS mutation cell lines.
Product Categories/Family for Belvarafenib, inhibitor
References
1. InHwan Bae, et al. Antitumor activity of the selective RAF inhibitor HM95573 in melanoma. AACR 2015. DOI: 10.1158/1538-7445.AM2015-2606
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Product Notes
The Belvarafenib (Catalog #AAA3601892) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Belvarafenib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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