Structure
SCH-772984, Inhibitor
SCH-772984
Purity
>98% (HPLC)
Synonyms
SCH-772984; SCH 772984; SCH772984; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=51mg/mL
Target
ERK
Receptor
ERK1; ERK2; MEK1
Chemical Name
3-Pyrrolidinecarboxamide, 1-[2-oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-, (3R)
SMILES
O=C([C@H]1CN(CC(N2CCN(C3=CC=C(C4=NC=CC=N4)C=C3)CC2)=O)CC1)NC5=CC6=C(NN=C6C7=CC=NC=C7)C=C5
Molecular Formula
C33H33N9O2
CAS Number
942183-80-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SCH-772984, inhibitor
A novel potent and selective inhibitor of ERK1/ERK2 with IC50 of 4nM/1nM, respectively; is highly selective, with only seven kinases of 300 showing >50% inhibition at 1uM; prevents MEK-mediated ERK phosphorylation, reduces pCRAF S289/S296/S301 phosphorylation; has nanomolar cellular potency in tumor cells with mutations in BRAF, NRAS, or KRAS and induces tumor regressions in xenograft models. Colon Cancer Phase 1 Clinical
Product Categories/Family for SCH-772984, inhibitor
References
1. Morris EJ, et al. Cancer Discov. 2013 Jul; 3 (7):742-50.
2. Wong DJ, et al. Mol Cancer. 2014 Aug 20; 13:194.
3. Chaikuad A, et al. Nat Chem Biol. 2014 Oct; 10 (10):853-60.
2. Wong DJ, et al. Mol Cancer. 2014 Aug 20; 13:194.
3. Chaikuad A, et al. Nat Chem Biol. 2014 Oct; 10 (10):853-60.
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Product Notes
The SCH-772984 (Catalog #AAA3606735) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SCH-772984, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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