Structure
LY2886721, Inhibitor
LY2886721
Purity
>98% (HPLC)
Synonyms
LY2886721; LY 2886721; LY-2886721; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=42mg/mL
Target
BACE
Receptor
BACE
Chemical Name
2-Pyridinecarboxamide, N-[3-[(4aS, 7aS)-2-amino-4a, 5-dihydro-4H-furo[3, 4-d][1, 3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro
SMILES
[H][C@@]12COC[C@@]1(N=C(N)SC2)C1=CC(NC(=O)C2=NC=C(F)C=C2)=CC=C1F|r,c:24,26,28,t:7,13,19,21|
Molecular Formula
C18H16F2N4O2S
CAS Number
1262036-50-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for LY2886721, inhibitor
LY2886721 is a highly potent, selective BACE1 aspartyl protease inhibitor with IC50 of 20.3 and 10.2nM for BACE1 and BACE2, shows no inhibition against cathepsin D, pepsin, renin, or other aspartyl proteases; produces a concentration-dependent decrease in Abeta1-40 and Abeta1-42 production in HEK293Swe cells (EC50s=10nM); demonstrates robust in vivo amyloid beta lowering effect in nonclinical animal models, shows similar potent and persistent amyloid beta lowering was observed in plasma and lumbar in clinical trials. Alzheimer Disease Phase 2 Discontinued
Product Categories/Family for LY2886721, inhibitor
References
1. Lahiri DK, et al. Alzheimers Dement. 2014 Oct; 10 (5 Suppl):S411-9.
2. May PC, et al. J Neurosci. 2015 Jan 21; 35 (3):1199-210.
3. Kumar D, et al. Eur J Med Chem. 2018 Mar 25; 148:436-452.
2. May PC, et al. J Neurosci. 2015 Jan 21; 35 (3):1199-210.
3. Kumar D, et al. Eur J Med Chem. 2018 Mar 25; 148:436-452.
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Product Notes
The LY2886721 (Catalog #AAA3601086) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LY2886721, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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