Structure
PF-06751979, Inhibitor
PF-06751979
Purity
>98% (HPLC)
Synonyms
PF-06751979; PF06751979; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 150mg/mL (329.31mM)
Ethanol: 50mg/mL (109.77mM)
Ethanol: 50mg/mL (109.77mM)
Target
BACE
Receptor
BACE
Chemical Name
N-(2-((4aR, 6S, 8aR)-2-amino-6-methyl-4, 4a, 5, 6-tetrahydropyrano[3, 4-d][1, 3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide
SMILES
CC1CC2CSC(=NC2(CO1)C3=NC(=CS3)NC(=O)C4=NC=C(C=C4)OC(F)F)N
Molecular Formula
C18H19F2N5O3S2
CAS Number
1818339-66-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PF-06751979, inhibitor
PF-06751979 is a potent, selective, brain penetrant BACE1 inhibitor with binding IC50 of 7.3, 27-fold selectivity over BACE2; shows BACE1 inhibition and sAPPbeta production in whole-cell assay with IC50 of 5.1 and 5nM; displays excellent brain penetration, potent in vivo efficacy, and broad selectivity over related aspartyl proteases including BACE2; demonstrates potent and dose-dependent Abeta lowering in human CSF with lacking hypopigmentation compared with AZD3239. Alzheimer Disease Phase 1 Clinical
Product Categories/Family for PF-06751979, inhibitor
References
1. O'Neill BT, et al. J Med Chem. 2018 Apr 3. doi: 10.1021/acs.jmedchem.8b00246.
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Product Notes
The PF-06751979 (Catalog #AAA3602796) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PF-06751979, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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