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Structure

LY2811376, Inhibitor

LY2811376

Purity
>98% (HPLC)
Synonyms
LY2811376; LY 2811376; LY-2811376; inhibitor
Ordering
 
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For Research Use Only!
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=31mg/mL
Target
BACE
Receptor
Abeta; BACE1
Chemical Name
4H-1, 3-Thiazin-2-amine, 4-[2, 4-difluoro-5-(5-pyrimidinyl)phenyl]-5, 6-dihydro-4-methyl-, (4S)
SMILES
NC1=N[C@](C)(C2=CC(C3=CN=CN=C3)=C(F)C=C2F)CCS1
Molecular Formula
C15H14F2N4S
CAS Number
1194044-20-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Structure

Related Product Information for LY2811376, inhibitor
A potent, orally available non-peptidic beta-secretase (BACE1) inhibitor with IC50 of 239nM in enzyme assays; demonstrates ~10-fold selectivity over BACE2, and >50-fold over aspartyl proteases cathepsin D, pepsin, or renin; produces profound Abeta-lowering effects in vivo. Alzheimer's Disease Phase 1 Discontinued
Product Categories/Family for LY2811376, inhibitor
References
1. May PC, et al. J Neurosci. 2011 Nov 16; 31 (46):16507-16.
2. Filser S, et al. Biol Psychiatry. 2015 Apr 15; 77 (8):729-39.
3. Portelius E, et al. Alzheimers Res Ther. 2014 Nov 17; 6 (5-8):75.
4. Cheret C, et al. EMBO J. 2013 Jul 17; 32 (14):2015-28.

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Product Notes

The LY2811376 (Catalog #AAA3600676) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LY2811376, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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