Structure
RO-5508887, Inhibitor
RO-5508887
Purity
>98% (HPLC)
Synonyms
RO-5508887; RO 5508887; RO5508887; RG-7129; RG7129; inhibitor
Purity/Purification
>98% (HPLC)
Target
BACE
Receptor
BACE
Chemical Name
5-Cyano-pyridine-2-carboxylic acid[3-((R)-2-amino-5, 5-difluoro-4-methyl-5, 6-dihydro-4H-[1, 3]oxazin-4-yl)-4-fluorophenyl]amide
SMILES
CC1(C(COC(=N1)N)(F)F)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)F
Molecular Formula
C18H14F3N5O2
CAS Number
1310347-50-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for RO-5508887, inhibitor
A potent, selective BACE inhibitor with IC50 of 30nM for BACE1, equally potent against BACE2 (IC50=40nM) but >1,000-fold selectivity over cathepsin D, cathepsin E, pepsin and renin; has IC50 of 18nM in HEK293APP cells and in neuronal cultures derived from human neuronal stem cells; significantly enhances antiamyloid effect combined with gantenerumab. Alzheimer Disease Phase 1 Clinical
Product Categories/Family for RO-5508887, inhibitor
References
1. Jacobsen H, et al. J Neurosci. 2014 Aug 27; 34 (35):11621-30.
Similar Products
Product Notes
The RO-5508887 (Catalog #AAA3601242) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "RO-5508887, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
