Rabbit GPR20 Polyclonal Antibody | anti-GPR20 antibody

GPR20 Polyclonal Antibody

Cat. Num. AAA3005898

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: GPR20; Polyclonal Antibody; GPR20 Polyclonal Antibody; G-protein coupled receptor 20; anti-GPR20 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GPR20 polyclonal antibody detects endogenous levels of GPR20 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 358

• Applicable Applications for anti-GPR20 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:1000; IF: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 313-358 of Human GPR20.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of GPR20 polyclonal antibody at 1:500 dilutionLane1:Hela cell lysateLane2:Mouse liver tissue lysateLane3:Rat liver tissue lysate)

Related Product Information for anti-GPR20 antibody

G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. G protein-coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR20 is a 358 amino acid membrane protein that constitutively activates G(i) proteins without ligand stimulation. Also, GPR20 may be involved in the control of intracellular cAMP levels and mitogenic signaling. Interestingly, GPR20 is expressed in liver and certain regions of the brain, including putamen, caudate and thalamus, but is not expressed in hypothalamus, pons and frontal cortex.

NCBI and Uniprot Product Information

• NCBI GI #: 89257346
• NCBI GeneID: 2843
• NCBI Accession #: NP_005284.2
• NCBI GenBank Nucleotide #: NP_005284.2
• UniProt Accession #: Q99678
• Molecular Weight: ~ 38kDa
• NCBI Official Full Name: G-protein coupled receptor 20
• NCBI Official Synonym Full Names: G protein-coupled receptor 20
• NCBI Official Symbol: GPR20
• NCBI Protein Information: G-protein coupled receptor 20
• UniProt Protein Name: G-protein coupled receptor 20
• Protein Family: G-protein coupled receptor
• UniProt Gene Name: GPR20
• UniProt Entry Name: GPR20_HUMAN

Uniprot Description

GPR20: Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: integral to plasma membrane; receptor complex

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway