Rabbit GPR116 Polyclonal Antibody | anti-GPR116 antibody

GPR116 Polyclonal Antibody

Cat. Num. AAA3007048

• Gene Names: ADGRF5; GPR116; KPG_001
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: GPR116; Polyclonal Antibody; GPR116 Polyclonal Antibody; Probable G-protein coupled receptor 116; KIAA0758; anti-GPR116 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GPR116 polyclonal antibody detects endogenous levels of GPR116 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1346

• Applicable Applications for anti-GPR116 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human GPR116
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of GPR116 pAb at 1:500 dilutionLane1:3T3-L1 whole cell lysate (40ug) Lane2:PC12 whole cell lysate (40ug) Lane3:HEK293T whole cell lysate (40ug) Lane4:A549 whole cell lysate (40ug))

Related Product Information for anti-GPR116 antibody

G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR116 (G protein-coupled receptor 116) is a 1, 346 amino acid multi-pass membrane protein that contains one SEA domain, one GPS domain and three Ig-like domains and belongs to the GPR family. Existing as a dilsulfide-liked homodimer at the cell surface, GPR116 exists as multiple alternatively spliced isoforms and is thought to play a role in regulating and maintaining proper acid-base balance throughout the cell.

NCBI and Uniprot Product Information

• NCBI GI #: 148719671
• NCBI GeneID: 221395
• NCBI Accession #: NP_001091988.1
• NCBI GenBank Nucleotide #: NP_001091988.1
• UniProt Accession #: Q8IZF2
• Molecular Weight: ~ 149kDa
• NCBI Official Full Name: adhesion G protein-coupled receptor F5
• NCBI Official Synonym Full Names: adhesion G protein-coupled receptor F5
• NCBI Official Symbol: ADGRF5
• NCBI Official Synonym Symbols: GPR116; KPG_001
• NCBI Protein Information: adhesion G protein-coupled receptor F5
• UniProt Protein Name: Probable G-protein coupled receptor 116
• UniProt Gene Name: GPR116
• UniProt Synonym Gene Names: KIAA0758
• UniProt Entry Name: GP116_HUMAN

Uniprot Description

GPR116: May have a role in the regulation of acid-base balance. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 6p12.3

Cellular Component: cell surface; integral to membrane; plasma membrane; cytoplasmic vesicle

Molecular Function: G-protein coupled receptor activity

Biological Process: fat cell differentiation; G-protein coupled receptor protein signaling pathway; regulation of lipid metabolic process; energy reserve metabolic process; glucose homeostasis; surfactant homeostasis