SDS-PAGE
B7-H4 recombinant protein
Recombinant Mouse B7-H4 Protein
Gene Names
Vtcn1; B7x; B7h4; B7s1; BC032925
Purity
> 95% as determined by SDS-PAGE
Synonyms
B7-H4; Recombinant Mouse B7-H4 Protein; V-set domain containing T-cell activation inhibitor 1; B7 homolog 4; Protein B7S1; VTCN1; B7h4; B7s1; B7x; BC032925; B7-H4 recombinant protein
Host
Human Cells
Purity/Purification
> 95% as determined by SDS-PAGE
Form/Format
Lyophilized powder from a 0.2 um filtered solution of PBS, pH7.4.
Sequence
Phe29-Pro258
Species
Mouse
Endotoxin
< 1.0 EU per ug as determined by the LAL method.
Tag
C-Fc
Reconstitution
We recommend that the vial be centrifuged to opening to bring the contents to the bottom. Do not mix by vortex.
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 mg/mL. Concentration is measured by UV-Vis.
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 mg/mL. Concentration is measured by UV-Vis.
Preparation and Storage
Storage:
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
SDS-PAGE
SDS-PAGE
Related Product Information for B7-H4 recombinant protein
Mouse V-set domain-containing T-cell activation inhibitor 1/VTCN1/B7-H4 is glycosylated member of the B7 family of immune co-stimulatory proteins. B7-H4 consists of extracellular domain (ECD) with one Ig-like V-set domain and one Ig-like C2-set domain. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Molecular Mass: 52.2 kDa
Actual Protein Molecular Mass: 70 - 90 kDa
Actual Protein Molecular Mass: 70 - 90 kDa
NCBI Official Full Name
V-set domain containing T-cell activation inhibitor 1
NCBI Official Synonym Full Names
V-set domain containing T cell activation inhibitor 1
NCBI Official Symbol
Vtcn1
NCBI Official Synonym Symbols
B7x; B7h4; B7s1; BC032925
NCBI Protein Information
V-set domain containing T-cell activation inhibitor 1
UniProt Protein Name
V-set domain containing T-cell activation inhibitor 1
UniProt Gene Name
Vtcn1
UniProt Synonym Gene Names
B7-H4
Uniprot Description
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Research Articles on B7-H4
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Product Notes
The B7-H4 vtcn1 (Catalog #AAA2553446) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Phe29-Pro2 58. It is sometimes possible for the material contained within the vial of "B7-H4, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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