BAFFR/TNFRSF13C Recombinant Protein | TNFRSF13C recombinant protein

BAFFR/TNFRSF13C Protein, Mouse, Recombinant (rFc Tag)

Cat. Num. AAA8122701

• Gene Names: Tnfrsf13c; Bcmd; Baffr; Bcmd1; BAFF-R; Bcmd-1; Lvis22; 2010006P15Rik
• Purity: >95% as determined by SDS-PAGE
• Synonyms: BAFFR/TNFRSF13C; BAFFR/TNFRSF13C Protein; Mouse; Recombinant (rFc Tag); Mouse BAFFR/TNFRSF13C/CD268 Protein (Fc Tag); 2010006P15Rik Protein; BAFF-R Protein; Baffr Protein; Bcmd Protein; Bcmd-1 Protein; Bcmd1 Protein; Lvis22 Protein; tumor necrosis factor receptor superfamily; member 13C; TNFRSF13C recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Ala71

• Species: Mouse
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Met
• Tag: C-rabbit IgG-Fc
• Protein Construction: A DNA sequence encoding the mouse Tnfrsf13c (NP_082351.1)(Met1-Ala71) was expressed with the Fc region of rabbit IgG at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for TNFRSF13C recombinant protein

Background: Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

References

Ashkenazi A, et al. (1998) Death receptors: signaling and modulation. Science. 281(5381): 1305-8.Losi CG, et al. (2005) Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency. J Clin Immunol. 25(5): 496-502.Hentges KE, et al. (2002) Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22. Genomics. 80(2): 204-12.

NCBI and Uniprot Product Information

• NCBI GI #: 16306481
• NCBI GeneID: 72049
• NCBI Accession #: NP_082351.1
• NCBI GenBank Nucleotide #: NM_028075.2
• UniProt Accession #: Q9D8D0
• Molecular Weight: 17,576 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 13C
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 13c
• NCBI Official Symbol: Tnfrsf13c
• NCBI Official Synonym Symbols: Bcmd; Baffr; Bcmd1; BAFF-R; Bcmd-1; Lvis22; 2010006P15Rik
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 13C
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 13C
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: Tnfrsf13c
• UniProt Synonym Gene Names: Baffr; Bcmd; Br3; BAFF-R
• UniProt Entry Name: TR13C_MOUSE

Uniprot Description

BAFF-R: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4); also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Cell cycle regulation; Membrane protein, integral; Cell surface

Cellular Component: membrane; integral to membrane; external side of plasma membrane

Biological Process: B cell costimulation; regulation of immune response; B cell homeostasis; immune system process; T cell costimulation; positive regulation of B cell proliferation; positive regulation of germinal center formation; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process