SDS-PAGE
Dim2 / TXNL4B recombinant protein
Recombinant Human Dim2 / TXNL4B Protein (His tag)
Gene Names
TXNL4B; DLP; Dim2
Purity
> 92 % as determined by SDS-PAGE
Synonyms
Dim2 / TXNL4B; Recombinant Human Dim2 / TXNL4B Protein (His tag); DLP; Dim2; Dim2 / TXNL4B recombinant protein
Host
E Coli
Purity/Purification
> 92 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, 20% glycerol, 0.1% Tween20, 50mM Arg, pH 7.5
Sequence Length
149
Application Notes
The recombinant human TXNL4B consisting of 165 amino acids and migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions as predicted.
Predicted N Terminal
Met
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for Dim2 / TXNL4B recombinant protein
Background: Dim2, also known as TXNL4B, is a member of the DIM1 family. The Dim protein family is composed of two classes, Dim1and Dim2, which share a common thioredoxin-like fold. They were originally identified for their role in cell cycle progression and have been found to interact with Prp6, an essential component of the spliceosome, which forms the bridge of U4/U6.U5-tri-snRNP. In spite of their biological and structural similarities, Dim1 and Dim2 proteins differ in many aspects. Dim1 bears distinctive structural motifs responsible for its interaction with other spliceosome components. Dim2 forms homodimers and contains specific domains required for its interactions with partners. This originality suggests that although both proteins are involved in pre-mRNA splicing, they are likely to be involved in different biological pathways. Dim2 roduced in E.Coli is a single, non-glycosylated polypeptide chain containing 185 amino acids and having a molecular mass of 21.1kDa. It is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Dim2 has a vital role in pro-mRNA splicing. Dim2 is required in cell cycle progression for S/G2 transition and interacts with PRPF6 subunit of the spliceosome.
Description: A DNA sequence encoding the human TXNL4B (Q9NX01) (Met 1-Ile 149) was expressed, with a polyhistide tag at the N-terminus.
Description: A DNA sequence encoding the human TXNL4B (Q9NX01) (Met 1-Ile 149) was expressed, with a polyhistide tag at the N-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
17,015 Da
NCBI Official Full Name
thioredoxin-like protein 4B isoform 1
NCBI Official Synonym Full Names
thioredoxin like 4B
NCBI Official Symbol
TXNL4B
NCBI Official Synonym Symbols
DLP; Dim2
NCBI Protein Information
thioredoxin-like protein 4B
UniProt Protein Name
Thioredoxin-like protein 4B
UniProt Gene Name
TXNL4B
UniProt Synonym Gene Names
DIM2; DLP
Uniprot Description
TXNL4B: Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition. Belongs to the DIM1 family.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 16q22.2
Cellular Component: snRNP U5; spliceosome; U4/U6 x U5 tri-snRNP complex
Molecular Function: protein binding
Biological Process: spliceosome assembly
Research Articles on Dim2 / TXNL4B
Similar Products
Product Notes
The Dim2 / TXNL4B txnl4b (Catalog #AAA2545299) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The recombinant human TXNL4B consisting of 165 amino acids and migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions as predicted. Researchers should empirically determine the suitability of the Dim2 / TXNL4B txnl4b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dim2 / TXNL4B, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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