SDS-PAGE
SELM / Selenoprotein M Recombinant Protein | SELM recombinant protein
Recombinant Human SELM / Selenoprotein M Protein (His tag)
SDS-PAGE
SDS-PAGE
Description: A DNA sequence encoding the mature form of human SELM (Q8WWX9) (Ala 24-Leu 145) was fused with a polyhistidine tag at the C-terminus and an initial Met at the N-terminus.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]
Uniprot Description
SELM: May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation. Belongs to the selenoprotein M/SEP15 family.
Protein type: Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 22q12.2
Molecular Function: protein binding
Research Articles on SELM
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Product Notes
The SELM selenom (Catalog #AAA2545294) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The recombinant human SELM comprises 133 amino acids and has a calculated molecular mass of 15.4KDa. It migrates as an approximately 19 kDa band d in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the SELM selenom for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SELM / Selenoprotein M, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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