SDS-PAGE
DIM1 / TXNL4A recombinant protein
Recombinant Human DIM1 / TXNL4A Protein (His tag)
SDS-PAGE
SDS-PAGE
Description: A DNA sequence encoding the human TXNL4A (P83876) (Met 1-Tyr 142) was expressed, with a polyhistidine tag at the N-terminus.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. This protein contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Uniprot Description
TXNL4A: Essential role in pre-mRNA splicing. Belongs to the DIM1 family.
Protein type: RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 18q23
Cellular Component: nucleoplasm; snRNP U5; spliceosome; U4/U6 x U5 tri-snRNP complex
Molecular Function: protein binding
Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; spliceosome assembly
Disease: Burn-mckeown Syndrome
Research Articles on DIM1 / TXNL4A
Similar Products
Product Notes
The DIM1 / TXNL4A txnl4a (Catalog #AAA2545511) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The recombinant human TXNL4A consists of 157 amino acids and has a calculated molecular mass of 18.6KDa. It migrates as an approximately 16 kDa band in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the DIM1 / TXNL4A txnl4a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DIM1 / TXNL4A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
