SDS-PAGE
TNFRSF4 / OX40 / CD134 recombinant protein
Recombinant Mouse TNFRSF4 / OX40 / CD134 Protein (Fc tag)
Gene Names
Tnfrsf4; Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L
Purity
> 92 % as determined by SDS-PAGE
Synonyms
TNFRSF4 / OX40 / CD134; Recombinant Mouse TNFRSF4 / OX40 / CD134 Protein (Fc tag); RP23-118E21.5; ACT35; CD134; Ly-70; Ox40; TXGP1L; Txgp1; TNFRSF4 / OX40 / CD134 recombinant protein
Host
Human Cells
Purity/Purification
> 92 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
272
Application Notes
The recombinant mouse TNFRSF4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 433 amino acids and has a calculated molecular mass of 48.3 kDa. As a result of glycosylation, the apparent molecular mass of the monomer is approximately 60 kDa in SDS-PAGE under reducing conditions.
Predicted N Terminal
Val 20
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for TNFRSF4 / OX40 / CD134 recombinant protein
Background: OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.
Description: A DNA sequence encoding the extracellular domain of mouse TNFRSF4 (P47741) (Met 1-Pro 211) was fused with the Fc region of human IgG1 at the C-terminus.
Description: A DNA sequence encoding the extracellular domain of mouse TNFRSF4 (P47741) (Met 1-Pro 211) was fused with the Fc region of human IgG1 at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
30,154 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 4
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 4
NCBI Official Symbol
Tnfrsf4
NCBI Official Synonym Symbols
Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L
NCBI Protein Information
tumor necrosis factor receptor superfamily member 4
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 4
UniProt Gene Name
Tnfrsf4
UniProt Synonym Gene Names
Ox40; Txgp1
Uniprot Description
TNFRSF4: Receptor for TNFSF4/OX40L/GP34.
Protein type: Apoptosis; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 4 E2|4 87.68 cM
Cellular Component: cell surface; external side of plasma membrane; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; tumor necrosis factor receptor activity
Biological Process: cellular defense response; immune response; inflammatory response; multicellular organismal development; negative regulation of cytokine secretion; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of B cell proliferation; positive regulation of immunoglobulin secretion; positive regulation of MAPKKK cascade; regulation of apoptosis; regulation of protein kinase activity; response to lipopolysaccharide; T cell proliferation
Research Articles on TNFRSF4 / OX40 / CD134
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Product Notes
The TNFRSF4 / OX40 / CD134 tnfrsf4 (Catalog #AAA2546779) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse TNFRSF4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 433 amino acids and has a calculated molecular mass of 48.3 kDa. As a result of glycosylation, the apparent molecular mass of the monomer is approximately 60 kDa in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the TNFRSF4 / OX40 / CD134 tnfrsf4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNFRSF4 / OX40 / CD134, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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