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OX40 Recombinant Protein | TNFRSF4 recombinant protein
OX40 Protein, Mouse, Recombinant
Gene Names
Tnfrsf4; Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L
Purity
>95% as determined by SDS-PAGE
Synonyms
OX40; OX40 Protein; Mouse; Recombinant; Mouse TNFRSF4/OX40/CD134 Protein; ACT35 Protein; CD134 Protein; Ly-70 Protein; Ox40 Protein; Txgp1 Protein; TXGP1L Protein; tumor necrosis factor receptor superfamily; member 4; TNFRSF4 recombinant protein
Host
HEK293 Cells
Purity/Purification
>95% as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Sequence
Met1-Pro211
Species
Mouse
Endotoxin
<1.0EU per ug protein as determined by the LAL method.
Predicted N Terminal
Val 20
Tag
C-cleavage
Protein Construction
A DNA sequence encoding the mouse Tnfrsf4 (NP_035789.1)(Met1-Pro211) was expressed with six amino acids (LEVLFQ) at the C-terminus.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
SDS-Page
SDS-Page
Related Product Information for TNFRSF4 recombinant protein
Background: OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.
Product Categories/Family for TNFRSF4 recombinant protein
References
Compaan D.M., et al. (2006).The crystal structure of the costimulatory OX40-OX40L complex. Structure 14:1321-1330.Kawamata S., et al. (1998).Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. J. Biol. Chem. 273:5808-5814. Byun M., (2013) Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J. Exp. Med. 210:1743-1759.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
30,154 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 4
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 4
NCBI Official Symbol
Tnfrsf4
NCBI Official Synonym Symbols
Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L
NCBI Protein Information
tumor necrosis factor receptor superfamily member 4; OX40 antigen; OX40L receptor; tax-transcriptionally activated glycoprotein 1
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 4
Protein Family
UniProt Gene Name
Tnfrsf4
UniProt Synonym Gene Names
Ox40; Txgp1
UniProt Entry Name
TNR4_MOUSE
Uniprot Description
TNFRSF4: Receptor for TNFSF4/OX40L/GP34.
Protein type: Apoptosis; Receptor, misc.; Membrane protein, integral
Cellular Component: cell surface; membrane; plasma membrane; integral to membrane; external side of plasma membrane
Molecular Function: protein binding; tumor necrosis factor receptor activity
Biological Process: regulation of apoptosis; T cell proliferation; tumor necrosis factor-mediated signaling pathway; negative regulation of transcription factor activity; negative regulation of cytokine secretion; programmed cell death; positive regulation of B cell proliferation; cellular defense response; positive regulation of immunoglobulin secretion; negative regulation of transcription, DNA-dependent; regulation of protein kinase activity; inflammatory response
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Product Notes
The TNFRSF4 tnfrsf4 (Catalog #AAA8122995) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Met1-Pro21 1. It is sometimes possible for the material contained within the vial of "OX40, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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