Transferrin Receptor 2 (TFR2) Recombinant Protein | TFR2 recombinant protein

Recombinant Transferrin Receptor 2 (TFR2)

Cat. Num. AAA2011670

• Gene Names: Tfr2; Trfr2
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Transferrin Receptor 2 (TFR2); Recombinant Transferrin Receptor 2 (TFR2); TFR2 recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with N-terminal His-Tag, its sequence is listed below.; MHHHHHHSSG LVPRGSGMKE TAAAKFERQH MDSPDLGTDD DDKAMADIGS EF-ITLLIFTG AFLLGYVAFR GSCQACGDSV LVVDEDVNPE DSGRTTLYWS DLQAMFLRFL GEGRMEDTIR LTSLRERVAG SARMATLVQD ILDKLSRQKL DHVWTDTHYV GLQFPDPAHA NTLHWVDADG SVQEQLPLED PEVYCPYSAT GNATGKLVYA HYGRSEDLQD LKAKGV
• Sequence Length: 798

• Applicable Applications for TFR2 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Mus musculus (Mouse)
• Expression System: Prokaryotic expression
• Residues: Ile86~Val259 (Accession # Q9JKX3) with N-terminal His-Tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 113204630
• NCBI GeneID: 50765
• NCBI Accession #: NP_056614.3
• NCBI GenBank Nucleotide #: NM_015799.4
• UniProt Accession #: Q9JKX3; Q920I6; Q99MQ9; Q9CPT2
• Molecular Weight: 25.0kDa
• NCBI Official Full Name: transferrin receptor protein 2 isoform b
• NCBI Official Synonym Full Names: transferrin receptor 2
• NCBI Official Symbol: Tfr2
• NCBI Official Synonym Symbols: Trfr2
• NCBI Protein Information: transferrin receptor protein 2
• UniProt Protein Name: Transferrin receptor protein 2
• Protein Family: Transferrin receptor protein
• UniProt Gene Name: Tfr2
• UniProt Synonym Gene Names: Trfr2; TfR2
• UniProt Entry Name: TFR2_MOUSE

Uniprot Description

TFR2: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3). HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable from that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. Belongs to the peptidase M28 family. M28B subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: membrane; cell; cytoplasm; integral to membrane; plasma membrane

Molecular Function: transferrin receptor activity

Biological Process: receptor-mediated endocytosis; iron ion homeostasis; cellular iron ion homeostasis