Chemical Structure
(Chemical structure of Rolipram (SIH-401), a Autophagy inhibitor. CAS #: 61413-54-5 . Molecular Formula: C16H21NO3. Molecular Weight: 275.35 g/mol.)
Rolipram Small Molecule
Rolipram
Purity
>98% (TLC); NMR (Conforms)
Synonyms
Rolipram; Autophagy inhibitor; 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one; Rolipram small molecule
Host
Synthetic
Purity/Purification
>98% (TLC); NMR (Conforms)
Form/Format
White to off-white solid
Solubility
Soluble to 75 mM in DMSO and to 75 mM in ethanol.
CAS Number
61413-54-5
Molecular Formula
C16H21NO3
SMILES
C1=C(C(=CC=C1C2CNC(C2)=O)OC)OC3CCCC3
InChI
1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
InChI Key
HJORMJIFDVBMOB-UHFFFAOYSA-N
PubChem CID
5092
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of Rolipram (SIH-401), a Autophagy inhibitor. CAS #: 61413-54-5 . Molecular Formula: C16H21NO3. Molecular Weight: 275.35 g/mol.)
Chemical Structure
(Chemical structure of Rolipram (SIH-401), a Autophagy inhibitor. CAS #: 61413-54-5 . Molecular Formula: C16H21NO3. Molecular Weight: 275.35 g/mol.)
Related Product Information for Rolipram small molecule
Rolipram has been observed to selectively inhibit cAMP-phosphodiesterase (PDE4) by recruiting PDE4 into cytosolic aggregates that are not membrane-encapsulated. A down-stream effect of this observation is the inhibition of autophagy. Under normal conditions, autophagosomes are coated with the autophagic marker light chain 3 (LC3). LC3 binds directly to p62 protein, which shuttles protein to aggresomes, eventually leading to an autophagic event. In the absence of LC3, protein aggregates will not undergo autophagy, and will remain as cytosolic aggregates, as seen with the inhibition of PDE4 by Rolipram.
Product Categories/Family for Rolipram small molecule
References
1. Kato H., et al. (1995) Eur J Pharmacol. 272(1): 107-10. 2. Christian F., et al. (2010) Cell Signal. 22(10): 1576-96. 3. Houslay M.D., & Christian F. (2010) Autophagy. 6(8): 1198-200.
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Product Notes
The Rolipram (Catalog #AAA808105) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Rolipram, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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