Chemical Structure
(Chemical structure of Leflunomide (SIH-368), a Immunosupressant. CAS #: 75706-12-6. Molecular Formula: C12H9F3N2O2. Molecular Weight: 270.21 g/mol.)
Leflunomide Small Molecule
Leflunomide
Purity
>98% (TLC: 5:95, CH3OH/CH2Cl2; Rf=0.65); NMR (Conforms)
Synonyms
Leflunomide; Immunosupressant; 5-methyl-N-[4-(trifluoromethyl) phenyl]-isoxazole-4-carboxamide; Leflunomide small molecule
Host
Synthetic
Purity/Purification
>98% (TLC: 5:95, CH3OH/CH2Cl2; Rf=0.65); NMR (Conforms)
Form/Format
White crystalline solid
Solubility
May be dissolved in DMSO (30 mg/ml); or Ethanol (27 mg/ml)
CAS Number
75706-12-6
Molecular Formula
C12H9F3N2O2
SMILES
CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F
InChI
1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
InChI Key
VHOGYURTWQBHIL-UHFFFAOYSA-N
PubChem CID
3899
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of Leflunomide (SIH-368), a Immunosupressant. CAS #: 75706-12-6. Molecular Formula: C12H9F3N2O2. Molecular Weight: 270.21 g/mol.)
Chemical Structure
(Chemical structure of Leflunomide (SIH-368), a Immunosupressant. CAS #: 75706-12-6. Molecular Formula: C12H9F3N2O2. Molecular Weight: 270.21 g/mol.)
Related Product Information for Leflunomide small molecule
Leflunomide is an Immuno-suppressant, it inhibits de novo synthesis of pyrimidine nucleotides and the activity of the protein kinase. It is a part of the known "disease-modifying anti-rheumatic drugs" (DMARD). It has been suggested that leflunomide modulates the expansion of activated autoimmune lymphocytes acting on the regression of rheumatoid conditions (1-2). It has been shown to have a double mechanism of action by slowing down and relieving the pain of rheumatoid arthritis. Studies have shown the lethal effects of Leflunomide after administration to mice in various doses (3).
Product Categories/Family for Leflunomide small molecule
References
1. Fukushima R., Kanamori S., Hirashiba M., et al. (2007) Reprod. Toxical. 24(3-4): 310-316. 2. Smolen JS., Emery P. (2000) Rheumatology. 39: 48-56. 3. Fox R.I., Herrman M.L., Franqou C.G., Wahl G.M., Morns R.E., Strand V. and Kirschbaum B.S. (1999) Clin Immunol 93(3): 198-208.
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Product Notes
The Leflunomide (Catalog #AAA808072) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Leflunomide, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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