Chemical Structure
(Chemical structure of AICAR (SIH-402), a Autophagy inducer. CAS #: 2627-69-2 . Molecular Formula: C9H14N4O5. Molecular Weight: 258.2 g/mol.)
AICAR small molecule
AICAR
Purity
>99% (TLC); NMR (Conforms)
Synonyms
AICAR; Autophagy inducer; N1-(beta-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide; AICAR small molecule
Host
Synthetic
Purity/Purification
>99% (TLC); NMR (Conforms)
Form/Format
Off-white solid
Solubility
Soluble to 75 mM in water and to 75 mM in DMSO.
CAS Number
2627-69-2
Molecular Formula
C9H14N4O5
SMILES
[C@@H]2([N]1C(=C(C(N)=O)N=C1)N)O[C@H](CO)[C@H]([C@H]2O)O
InChI
1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
InChI Key
RTRQQBHATOEIAF-UUOKFMHZSA-N
PubChem CID
17513
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of AICAR (SIH-402), a Autophagy inducer. CAS #: 2627-69-2 . Molecular Formula: C9H14N4O5. Molecular Weight: 258.2 g/mol.)
Chemical Structure
(Chemical structure of AICAR (SIH-402), a Autophagy inducer. CAS #: 2627-69-2 . Molecular Formula: C9H14N4O5. Molecular Weight: 258.2 g/mol.)
Related Product Information for AICAR small molecule
AICAR is an adenosine analog that when phosphorylated forms 5-aminoimidazole-4-carboxamide-1-D-ribofuranosyl-5'-monophosphate (ZMP) which proceeds to activate adenosine monophosphate-activated protein kinase (AMPK). This process in turn stimulates glucose uptake by skeletal muscle in an insulin-dependent manner. Autophagy is initiated by the UNC-51-like kinase 1/2 complex (ULK1 and ULK2). Under basal conditions, autophagy is negatively regulated due to the phosphorylation of ULK1 at serine-757 by mTORC1. During starvation, autophagy is positively regulated by ULK1/2 when it is phosphorylated at serine-555 and serine-777 by AMPK. Therefore, the activation of AMPK by AICAR, in turn will induce autophagy.
Product Categories/Family for AICAR small molecule
References
1. Jhun B.S., et al. (2004) Biochem Biophys Res Commun. 318(2): 372-80. 2. Huang H., et al. (2013) Autophagy. 9(2): 175-95.
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Product Notes
The AICAR (Catalog #AAA808106) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AICAR, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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