RBMXL2 sirna

RBMXL2 siRNA (Human)

Cat. Num. AAA8236811

• Gene Names: RBMXL2; HNRPGT; HNRNPGT; HNRNPG-T
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: RBMXL2; RBMXL2 siRNA (Human); HNRNPGT; RNA-binding motif protein. X-linked-like-2; Testis-specific heterogeneous nuclear ribonucleoprotein G-T; hnRNP G-T; RBMXL2 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: RBMXL2 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 392

• Applicable Applications for RBMXL2 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human RBMXL2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for RBMXL2 sirna

siRNA to inhibit RBMXL2 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 153252068
• NCBI GeneID: 27288
• NCBI Accession #: NP_055284.3
• NCBI GenBank Nucleotide #: NM_014469.4
• UniProt Accession #: O75526; Q6PEZ2; Q9NQU0
• Molecular Weight: 42,814 Da
• NCBI Official Full Name: RNA-binding motif protein, X-linked-like-2
• NCBI Official Synonym Full Names: RNA binding motif protein, X-linked-like 2
• NCBI Official Symbol: RBMXL2
• NCBI Official Synonym Symbols: HNRPGT; HNRNPGT; HNRNPG-T
• NCBI Protein Information: RNA-binding motif protein, X-linked-like-2
• UniProt Protein Name: RNA-binding motif protein, X-linked-like-2
• Protein Family: RNA-binding motif protein
• UniProt Gene Name: RBMXL2
• UniProt Synonym Gene Names: HNRNPGT; hnRNP G-T
• UniProt Entry Name: RMXL2_HUMAN

NCBI Description

This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility. [provided by RefSeq, Jul 2008]

Uniprot Description

RBMXL2:

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: nucleus; ribonucleoprotein complex

Molecular Function: RNA binding; nucleotide binding