anti-Human F13B Antibody | anti-F13B antibody

F13B Antibody

Cat. Num. AAA859005

• Gene Names: F13B; FXIIIB
• Reactivity: Human
• Applications: Immunohistochemistry, Immunofluorescence, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: F13B; F13B Antibody; Coagulation factor XIII B chain; Protein-glutamine gamma-glutamyltransferase B chain; Transglutaminase B chain; Fibrin-stabilizing factor B subunit; anti-F13B antibody

• Reactivity: Human
• Specificity: F13B antibody detects endogenous levels of total F13B protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 661

• Applicable Applications for anti-F13B antibody: Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; IF: 1:100-1:500; ELISA: 1:20000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human F13B.
• Preparation and Storage: Store at-20 degree C for 1 year.

Testing Data

(Peptide-+)

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemistry analysis of paraffin-embedded human heart tissue using F13B antibody. Immunofluorescence analysis of HuvEc cells, using F13B antibody.)

Product Categories/Family for anti-F13B antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Gregory S.G., Nature 441:315-321(2006). Liu T., J. Proteome Res. 4:2070-2080(2005). Cargill M., Nat. Genet. 23:373-373(1999).

NCBI and Uniprot Product Information

• NCBI GI #: 110611237
• NCBI GeneID: 2165
• NCBI Accession #: NP_001985.2
• NCBI GenBank Nucleotide #: NM_001994.2
• UniProt Accession #: P05160; Q5VYL5; A8K3E5
• Molecular Weight: 75,511 Da
• NCBI Official Full Name: coagulation factor XIII B chain
• NCBI Official Synonym Full Names: coagulation factor XIII B chain
• NCBI Official Symbol: F13B
• NCBI Official Synonym Symbols: FXIIIB
• NCBI Protein Information: coagulation factor XIII B chain
• UniProt Protein Name: Coagulation factor XIII B chain
• Protein Family: Coagulation factor
• UniProt Gene Name: F13B

NCBI Description

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

Uniprot Description

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.