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398 results for "ERK inhibitor" - showing 1-50
Chemical Structure
TCS ERK 11e (VX-11e), Inhibitor (Cat# AAA385719)
Full Name
TCS ERK 11e (VX-11e)
Purity
>98%
Pricing
$230/10 mg | $395/25 mg | $550/50 mg | $975/100 mg | $4,335/5x100 mg
Western Blot (WB)
(Western Blot analysis of purified MAPK phospho-proteins or extracts from NIH/3T3 cells treated with UV light and PDGF, using MBS600367 (upper), M2352-05E (middle), and MBS600367.)
MAP Kinase p44/42, Monoclonal Antibody (Cat# AAA600367)
Full Name
MAP Kinase p44/42, phosphorylated (Thr202/Tyr204) (MAPK3/MAPK1, Mitogen-activated Protein Kinase 1, MAP Kinase 1, MAPK 1, ERT1, Extracellular Signal-regulated Kinase 2, ERK-2, MAP Kinase Isoform p42, p42-MAPK, Mitogen-activated Protein Kinase 2, MAP Kinas
Reactivity
Drosophila, Human, Monkey, Mouse, Porcine, Rat0
Applications
WB, FC/FACS, IF
Purity
Supernatant
Supernatant
Supernatant
Pricing
$650/0.2 mL | $2,905/5x0.2 mL
Western Blot (WB)
(Western blot analysis of extracts from various cells, using MBS608615)
MAP Kinase p44/42, Monoclonal Antibody (Cat# AAA608615)
Full Name
MAP Kinase p44/42 (MAPK3/MAPK1, Mitogen-activated Protein Kinase 1, MAP Kinase 1, MAPK 1, ERT1, Extracellular Signal-regulated Kinase 2, ERK-2, MAP Kinase Isoform p42, p42-MAPK, Mitogen-activated Protein Kinase 2, MAP Kinase 2, MAPK 2, ERK2, PRKM1, PRKM2
Reactivity
Hamster, Human, Monkey, Mouse, Porcine, Rat
Applications
EL/EIA, WB, IHC
Purity
Purified
Purified
Purified
Pricing
$610/0.1 mL | $2,730/5x0.1 mL
Testing Data
(Specificity and sensitivity of MBS615382. The antibody reacts specifically with as little as 0.25ng of phosphorylated p42 MAP kinase and does not cross-react with up to 4ug of nonphosphorylated p42 MAP kinase.)
MAP Kinase p44, p42, Polyclonal Antibody (Cat# AAA615382)
Full Name
MAP Kinase p44, p42, phosphorylated (Thr202, Tyr204) (MAPK3/MAPK1, Mitogen-activated Protein Kinase 1, MAP Kinase 1, MAPK 1, ERT1, Extracellular Signal-regulated Kinase 2, ERK-2, MAP Kinase Isoform p42, p42-MAPK, Mitogen-activated Protein Kinase 2, MAP Ki
Gene Names
MAPK3; ERK1; ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK
Reactivity
Bovine, Chicken, Hamster, Human, Monkey, Mouse, Rat
Applications
EL/EIA, WB, IP, ICC, FC/FACS, IF
Purity
Affinity Purified
Purified by Protein A and peptide affinity chromatography.
Purified by Protein A and peptide affinity chromatography.
Pricing
$645/0.2 mL | $2,885/5x0.2 mL
Structure
Trametinib, Inhibitor (Cat# AAA576333)
Full Name
Trametinib (GSK1120212)
Purity
99.88%
Pricing
$185/5 mg | $195/10 mg | $210/50 mg | $240/100 mg | $275/200 mg | $195/1 mL (in DMSO) | $970/5x200 mg
Structure
Ibrutinib, Inhibitor (Cat# AAA575412)
Full Name
Ibrutinib (PCI-32765)
Purity
99.79%
Pricing
$185/5 mg | $200/10 mg | $205/50 mg | $215/100 mg | $235/200 mg | $200/1 mL (in DMSO) | $795/5x200 mg
Testing Data
(Peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK.)
JIP-1, Inhibitor (Cat# AAA8506491)
Full Name
JIP-1 (153-163)
Gene Names
Mapk8ip1; IB1; Jip1; Skip; JIP-1; Prkm8ip; mjip-2a
Purity
>99%
Pricing
$390/1 mg | $1,705/5x1 mg
Testing Data
(Data show effective inhibition of ERK1/2 phosphorylation in insulin + LIF treated 3T3-L1 adipocytes, using M2865-17B.)
MEK1 Inhibitor, Inhibitor (Cat# AAA655336)
Full Name
MEK1 Inhibitor (PD98059, 2'-amino-3'- methoxyflavone)
Gene Names
MAP2K1; CFC3; MEK1; MKK1; MAPKK1; PRKMK1
Purity
Highly Purified
~95% (HPLC)
~95% (HPLC)
Pricing
$560/5 mg | $2,515/5x5 mg
Structure
(Structure of PD 98059)
MEK1 Inhibitor, Inhibitor (Cat# AAA655442)
Full Name
MEK1 Inhibitor (PD98059, 2'-amino-3'-methoxyflavone)
Gene Names
MAP2K1; CFC3; MEK1; MKK1; MAPKK1; PRKMK1
Purity
Highly Purified
~99%
~99%
Pricing
$275/5 mg | $1,225/5x5 mg
Testing Data
(PLX4720, a 7-azaindole derivative that inhibits B-RafV600E with an IC50 of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX4720 preferentially inhibits the active B-RafV600E kinase compared with a broad spectrum of other kinases (IC50:B-Raf=160 nM, BRK=130 nM, other kinases >1000nM), and potent cytotoxic effects are also exclusive to cells bearing the V600E allele (GI5010 uM). [1]Consistent with the high degree of selectivity, ERK phosphorylation is potently inhibited by PLX4720 in B-RafV600E -bearing tumor cell lines but not in cells lacking oncogenic B-Raf. [1]In B-RafV600E -dependent tumor xenograft models, orally dosed PLX4720 causes significant tumor growth delays, including tumor regressions, without evidence of toxicity. [1])
PLX-4720, Inhibitor (Cat# AAA8506422)
Full Name
PLX-4720
Purity
>99%
Pricing
$295/5 mg | $1,255/5x5 mg
Testing Data
(Gefitinib (Iressa) is a novel potent EGFR tyrosine kinase and Akt phosphorylations inhibitor with IC50 of 37, 26 and 57 nM for Tyr1173, Tyr1173 and Tyr992 in, respectively, the low and high EGFR expressing cell lines. Immunoblot analysis of whole cell lysates revealed that in general gefitinib effectively inhibited all tyrosine phosphorylation sites on EGFR in both the high and low-EGFR-expressing cell lines. However, the phosphorylation sites Tyr1173 and Tyr992 were less sensitive requiring higher concentrations of gefitinib for inhibition. As was the case for ERK, gefitinib fails to effectively inhibit AKT phosphorylation in the high-EGFR- expressing cell line indicating that EGFR is not the major activator of AKT in this cell line. The low IC50 (7 nM), however show that the weak induction of AKT phosphorylation by EGFR in this cell line is efficiently blocked by gefitinib. Gefitinib inhibits AKT phosphorylations, with IC50 values of 220 and 263 nM, in the low-EGFR- and -EGFRvIII-expressing cell lines, respectively. [1] MCF10A cells are nontransformed breast epithelial cells that require EGF to proliferate.)
Gefitinib, Inhibitor (Cat# AAA8506564)
Full Name
Gefitinib (Iressa)
Purity
>99%
Pricing
$295/1 g | $1,255/5x1 g
Structure
SCH772984, Inhibitor (Cat# AAA578640)
Full Name
SCH772984
Purity
99.75%
Pricing
$225/2 mg | $240/5 mg | $285/10 mg | $420/25 mg | $570/50 mg | $270/1 mL (in DMSO) | $2,295/5x50 mg
Hydroxysafflor yellow A, Inhibitor (Cat# AAA578539)
Full Name
Hydroxysafflor yellow A
Purity
99.88%
Pricing
$195/5 mg | $225/10 mg | $270/25 mg | $355/50 mg | $535/100 mg | $855/200 mg | $3,575/5x200 mg
Galangin, Inhibitor (Cat# AAA578534)
Full Name
Galangin
Purity
98.2%
Pricing
$190/5 mg | $200/10 mg | $225/25 mg | $265/50 mg | $325/100 mg | $470/200 mg | $195/1 mL (in DMSO) | $1,845/5x200 mg
Jaceosidin, Inhibitor (Cat# AAA579797)
Full Name
Jaceosidin
Purity
98.47%
Pricing
$200/1 mg | $255/5 mg | $305/10 mg | $480/25 mg | $1,900/5x25 mg
Structure
GDC-0994, Inhibitor (Cat# AAA579053)
Full Name
GDC-0994
Purity
98.1%
Pricing
$200/1 mg | $215/2 mg | $235/5 mg | $245/10 mg | $350/25 mg | $440/50 mg | $235/1 mL (in DMSO) | $1,700/5x50 mg
6- (2-O-alpha-L-Arabinopyranosyl-beta-D-glucopyranosyl)-2-[4- (beta-D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one, Inhibitor (Cat# AAA579825)
Full Name
6- (2-O-alpha-L-Arabinopyranosyl-beta-D-glucopyranosyl)-2-[4- (beta-D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one
Purity
99.9%
Pricing
$180/1 mg | $215/5 mg | $255/10 mg | $870/5x10 mg
B-Raf inhibitor 1, Inhibitor (Cat# AAA5750031)
Full Name
B-Raf inhibitor 1 dihydrochloride
Purity
98.4%
Pricing
$205/2 mg | $245/5 mg | $315/10 mg | $905/50 mg | $1,595/100 mg | $6,915/5x100 mg
Chemical Structure
(Chemical structure of AZD6244 (SIH-495), a ERK kinase inhibitor. CAS #: 606143-52-6. Molecular Formula: C17H15BrClFN4O3. Molecular Weight: 457.7 g/mol.)
AZD6244, Small Molecule (Cat# AAA808194)
Full Name
AZD6244
Purity
>=98%
Pricing
$255/5 mg | $630/25 mg | $2,600/5x25 mg | $925/5x5 mg
PRKCA / Protein Kinase C Alpha Type, Recombinant Protein (Cat# AAA2902480)
Full Name
Human PRKCA / Protein Kinase C Alpha Type Recombinant Protein
Gene Names
PRKCA; AAG6; PKCA; PRKACA; PKCI+/-; PKCalpha; PKC-alpha
Applications
EIA, WB, AP
Purity
>95% by SDS-PAGE
10-Gingerol, Inhibitor (Cat# AAA579845)
Full Name
10-Gingerol
Purity
99.17%
Pricing
$180/1 mg | $215/5 mg | $255/10 mg | $215/1 mL (in DMSO) | $870/5x10 mg
Xanthyletin, Inhibitor (Cat# AAA5761020)
Full Name
Xanthyletin
Purity
98.00%
Pricing
$315/1 mg | $550/5 mg | $755/10 mg | $1,255/25 mg | $1,815/50 mg | $7,905/5x50 mg
Chemical Structure
Takinib, Inhibitor (Cat# AAA5750414)
Full Name
Takinib
Purity
98.0%
Pricing
$170/1 mg | $215/5 mg | $265/10 mg | $355/25 mg | $480/50 mg | $715/100 mg | $200/1 mL (in DMSO) | $2,945/5x100 mg
Broussonin E, Inhibitor (Cat# AAA5761988)
Full Name
Broussonin E
Purity
98.00%
Pricing
$370/1 mg | $1,375/5x1 mg
Fustin, Inhibitor (Cat# AAA5760383)
Full Name
Fustin
Purity
98.00%
Pricing
$335/1 mg | $1,220/5x1 mg
Rubrofusarin-6-O-beta-D-gentiobioside, Inhibitor (Cat# AAA5760877)
Full Name
Rubrofusarin-6-O-beta-D-gentiobioside
Purity
98.00%
Pricing
$305/1 mg | $640/5 mg | $900/10 mg | $1,505/25 mg | $2,200/50 mg | $9,625/5x50 mg
Structure
PLX-7904, Inhibitor (Cat# AAA3601638)
Full Name
PLX-7904
Purity
>98% (HPLC)
Pricing
$200/2 mg | $235/5 mg | $290/10 mg | $390/25 mg | $1,465/5x25 mg
Structure
Structure
Boehmenan, Inhibitor (Cat# AAA5761975)
Full Name
Boehmenan
Purity
98.00%
Pricing
$390/1 mg | $1,475/5x1 mg
Avicularin, Inhibitor (Cat# AAA5750960)
Full Name
Avicularin
Purity
97.02%
Pricing
$210/1 mg | $670/5x1 mg
Structure
SDS-Page
(Recombinant MAP2K2 protein gel 10% SDS-PAGE with Coomassie blue staining MW: 45.7 kDa Purity: >90%)
MAP2K2, Recombinant Protein (Cat# AAA389377)
Full Name
Recombinant MAP2K2 protein
Gene Names
MAP2K2; CFC4; MEK2; MKK2; MAPKK2; PRKMK2
Pricing
$565/0.02 mg | $2,475/5x0.02 mg
Torilin, Inhibitor (Cat# AAA5763230)
Full Name
Torilin
Purity
98.00%
Pricing
$335/1 mg | $1,220/5x1 mg
KO-947, Inhibitor (Cat# AAA5764263)
Full Name
KO-947
Purity
98.00%
Pricing
$265/5 mg | $335/10 mg | $515/25 mg | $830/50 mg | $1,415/100 mg | $6,095/5x100 mg
Prunetin, Inhibitor (Cat# AAA5750804)
Full Name
Prunetin
Purity
98.00%
Pricing
$290/1 mg | $1,045/5x1 mg
Structure
OTS-964, Inhibitor (Cat# AAA3601360)
Full Name
OTS-964
Purity
>98% (HPLC)
Pricing
$235/2 mg | $255/5 mg | $340/10 mg | $510/25 mg | $790/50 mg | $3,260/5x50 mg
Cajanin, Inhibitor (Cat# AAA5760201)
Full Name
Cajanin
Purity
98.00%
Pricing
$370/1 mg | $1,375/5x1 mg
Rupestonic acid, Inhibitor (Cat# AAA5760878)
Full Name
Rupestonic acid
Purity
98.00%
Pricing
$360/1 mg | $1,325/5x1 mg
Structure
Structure
BAY-293, Inhibitor (Cat# AAA3603598)
Full Name
BAY-293
Purity
>98% (HPLC)
Pricing
$375/5 mg | $555/10 mg | $850/25 mg | $3,525/5x25 mg
Farrerol, Inhibitor (Cat# AAA5750971)
Full Name
Farrerol
Purity
98.00%
Pricing
$195/1 mg | $435/50 mg | $590/100 mg | $230/1 mL (in DMSO) | $2,375/5x100 mg
Mogrol, Inhibitor (Cat# AAA5761048)
Full Name
Mogrol
Purity
98.00%
Pricing
$210/1 mg | $305/5 mg | $405/10 mg | $705/25 mg | $315/1 mL (in DMSO) | $2,895/5x25 mg
Structure
4-P-PDOT, Inhibitor (Cat# AAA5754435)
Full Name
4-P-PDOT
Purity
98.00%
Pricing
$200/1 mg | $265/5 mg | $265/1mL*10mM (in DMSO) | $915/5x1mL*10mM (in DMSO)
Structure
Ravoxertinib hydrochloride, Inhibitor (Cat# AAA5754898)
Full Name
Ravoxertinib hydrochloride
Purity
98.00%
Pricing
$235/2 mg | $275/5 mg | $355/10 mg | $765/50 mg | $280/1mL*10mM (in DMSO) | $3,160/5x50 mg
Chrysoeriol, Inhibitor (Cat# AAA5760228)
Full Name
Chrysoeriol
Purity
98.00%
Pricing
$240/1 mg | $395/5 mg | $525/10 mg | $855/25 mg | $1,125/50 mg | $1,765/100 mg | $2,585/200 mg | $11,365/5x200 mg
Isocryptotanshinone, Inhibitor (Cat# AAA5760503)
Full Name
Isocryptotanshinone
Purity
98.00%
Pricing
$485/1 mg | $1,890/5x1 mg
alpha-Viniferin, Inhibitor (Cat# AAA5760122)
Full Name
alpha-Viniferin
Purity
98.00%
Pricing
$300/1 mg | $1,055/5x1 mg
FMK, Inhibitor (Cat# AAA5764557)
Full Name
FMK
Purity
98.00%
Pricing
$855/25 mg | $1,220/50 mg | $1,720/100 mg | $7,450/5x100 mg
Structure
