Structure
AS1940477, Inhibitor
AS1940477
Purity
>98% (HPLC)
Synonyms
AS1940477; AS 1940477; AS-1940477; inhibitor
Purity/Purification
>98% (HPLC)
Target
p38 MAPK
Receptor
p38 MAPK
Chemical Name
6-[(6R)-2-(4-fluorophenyl)-6-(hydroxymethyl)-4, 5, 6, 7-tetrahydropyrazolo[1, 5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one
SMILES
O=C1C=CC(C2=C3NC[C@@H](CO)CN3N=C2C4=CC=C(F)C=C4)=NN1C5=CC=CC=C5C
Molecular Formula
C24H22FN5O2
CAS Number
928344-12-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AS1940477, inhibitor
A potent, selective, orally active p38alpha/p38beta inhibitor with IC50 of 11.2/36.5nM respectively, with no effect on p38gamma and delta isoforms (IC50>1uM); displays no activity against a panel of 100 protein kinases, including JNK2, EGFR, Akt and Pim; inhibits LPS- or PHA-induced production of proinflammatory cytokines, including TNFalpha, IL-1beta, and IL-6 at low concentrations (LPS/TNFalpha, IC50=0.45nM; PHA/TNFalpha, IC50=0.40nM) in human PBMCs, also inhibits TNFalpha- and IL-1 beta-induced production of IL-6, PGE (2), and MMP-3 in human synovial stromal cells; potently inhibits TNF production in whole blood (IC50=12nM) and effectively inhibits TNFalpha production induced by LPS in rats with long-acting anti-inflammatory effect.
Product Categories/Family for AS1940477, inhibitor
References
1. Asano T, et al. J Med Chem. 2012 Sep 13; 55 (17):7772-85.
2. Terajima M, et al. Eur J Pharmacol. 2013 Jan 5; 698 (1-3):455-62.
2. Terajima M, et al. Eur J Pharmacol. 2013 Jan 5; 698 (1-3):455-62.
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Product Notes
The AS1940477 (Catalog #AAA3606643) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AS1940477, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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