Structure
BAY-293, Inhibitor
BAY-293
Purity
>98% (HPLC)
Synonyms
BAY-293; BAY293; BAY 293; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=125mg/mL (278.66mM)
Target
Ras
Receptor
KRAS-SOS1interaction
Chemical Name
(R)-6, 7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine
SMILES
C[C@@H](NC1=C2C=C(OC)C(OC)=CC2=NC(C)=N1)C3=CC(C4=CC=CC=C4CNC)=CS3
Molecular Formula
C25H28N4O2S
CAS Number
2244904-70-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BAY-293, inhibitor
BAY-293 (BAY293, BAY 293) is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21nM; displays no significant activity against KRAS WT-CRAF RBD, CDC42 and EGFR (>20uM); blocks reloading of KRAS with GTP, does not stabilize KRASWT or KRASG12C; inhibits the activation of RAS in HeLa cells with IC50 of 410nM, efficiently inhibits pERK levels in K562 cells after incubation for 60 min without affecting total protein levels of ERK (IC50=180nM); shows antiproliferative activity against wild-type KRAS cell lines (K562, MOLM-13; IC50~1uM) and cell lines with KRASG12C mutation (NCI-H358, Calu-; IC50~3uM) by preventing formation of the KRAS-SOS1 complex, also shows synergic antiproliferative effect with covalent KRASG12C inhibitor ARS-853; BAY-293 is a valuable chemical probe for investigation of the activation of KRAS by SOS1.
Product Categories/Family for BAY-293, inhibitor
References
1. Hillig RC, et al. Proc Natl Acad Sci U S A. 2019 Jan 25. pii: 201812963. doi: 10.1073/pnas.1812963116.
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Product Notes
The BAY-293 (Catalog #AAA3603598) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BAY-293, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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