ARHB Blocking Peptide | RHOB blocking peptide

ARHB Antibody (Center) Blocking peptide

• Gene Names: RHOB; ARH6; ARHB; RHOH6; MST081; MSTP081
• Synonyms: ARHB; ARHB Antibody (Center) Blocking peptide; Rho-related GTP-binding protein RhoB; Rho cDNA clone 6; h6; RHOB; ARH6; RHOB blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 196

• Cellular Location: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note: Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RHOB blocking peptide

Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.

NCBI and Uniprot Product Information

• NCBI GI #: 51338601
• NCBI GeneID: 388
• UniProt Accession #: P62745; P01121; Q5U0H6; Q7RTN5; Q7RTR9; Q9CUV7; B2R692
• Molecular Weight: 22,123 Da
• NCBI Official Full Name: Rho-related GTP-binding protein RhoB
• NCBI Official Synonym Full Names: ras homolog family member B
• NCBI Official Symbol: RHOB
• NCBI Official Synonym Symbols: ARH6; ARHB; RHOH6; MST081; MSTP081
• NCBI Protein Information: rho-related GTP-binding protein RhoB
• UniProt Protein Name: Rho-related GTP-binding protein RhoB
• Protein Family: Rho-related GTP-binding protein
• UniProt Gene Name: RHOB
• UniProt Synonym Gene Names: ARH6; ARHB; h6
• UniProt Entry Name: RHOB_HUMAN

Uniprot Description

RHOB: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.

Protein type: G protein; Tumor suppressor; Motility/polarity/chemotaxis; G protein, monomeric; G protein, monomeric, Rho

Chromosomal Location of Human Ortholog: 2p24

Cellular Component: cleavage furrow; cytosol; endosome membrane; focal adhesion; nucleus; plasma membrane

Molecular Function: GTP binding; GTPase activity; protein binding

Biological Process: apoptosis; cell adhesion; cytokinesis; endosome to lysosome transport; negative regulation of cell cycle; negative regulation of cell migration; platelet activation; positive regulation of angiogenesis; positive regulation of apoptosis; regulation of cell migration; regulation of small GTPase mediated signal transduction; Rho protein signal transduction