Rat RGC32/Response Gene To Complement 32 Protein ELISA Kit | RGC32 elisa kit
Rat RGC32/Response Gene To Complement 32 Protein ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
increased expression is detected in oligodendrocytes in response to complement activation; may play a role in cell cycle activation [RGD, Feb 2006]
Uniprot Description
RGC32: modulates the activity of cell cycle-specific kinases. Interacts with CDK1 and PLK1. Enhances CDK1 activity and contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. Interacts with SMAD3. Cytoplasmic in unstimulated cells; translocates to the nucleus following activation by complement. Associated with the centrosome during prometaphase and metaphase. Induced by Epstein-Barr virus (EBV). Up-regulated in aorta endothelial cells in response to complement activation. Important in vascular smooth muscle cell (VSMC) differentiation following transforming growth factor-beta (TGF-beta) induction. Its expression is greatly induced by TGF-beta in neural crest cells, leading to the induction of VSMC gene promoters. Smad and RhoA signaling are important for RGC-32 activation in neural crest cells. Forms a complex with hnRNP A/B that regulates the transcription of VSMC differentiation genes. Two isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Protein kinase, regulatory subunit
Cellular Component: centrosome; cytoplasm; nucleus
Molecular Function: protein kinase binding; protein kinase activator activity
Biological Process: positive regulation of mitosis; negative regulation of cytokine secretion; positive regulation of collagen biosynthetic process; negative regulation of blood vessel endothelial cell migration; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; complement activation; negative regulation of cell proliferation; negative regulation of angiogenesis; negative regulation of exit from mitosis; positive regulation of stress fiber formation; negative regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; regulation of cyclin-dependent protein kinase activity; positive regulation of cytokine secretion
Research Articles on RGC32
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Product Notes
The Rat RGC32 rgcc (Catalog #AAA2890940) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2890940 ELISA Kit recognizes Rat RGC32. It is sometimes possible for the material contained within the vial of "RGC32/Response Gene To Complement 32 Protein, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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