Rabbit anti-Mouse YKL-40/CHI3L1 Polyclonal Antibody | anti-CHI3L1 antibody

Anti-YKL-40/CHI3L1 Antibody, Rabbit Polyclonal

Cat. Num. AAA8112166

• Gene Names: Chil1; Gp39; Brp39; Chi3l1; AW208766
• Reactivity: Mouse
• Applications: ELISA
• Purity: Protein A
• Synonyms: YKL-40/CHI3L1; Polyclonal Antibody; Anti-YKL-40/CHI3L1 Antibody; Rabbit Polyclonal; CHI3L1/YKL40 Antibody; Rabbit PAb; chitinase 3 like 1; Anti-AW208766 Antibody; Anti-Brp39 Antibody; Anti-Gp39 Antibody; anti-CHI3L1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse CHI3L1/YKL40
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-CHI3L1 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:1000-1:2000
• Immunogen: Recombinant Mouse CHI3L1/YKL40 Protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Mouse CHI3L1/YKL40 (rM CHI3L1/YKL40). Total IgG was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CHI3L1 antibody

Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC cultures and at low levels in subconfluent proliferating cultures. CHI3L1 is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. In contrast to many other monocyto/macrophage markers, its expression is absent in monocytes and strong induced during late stages of human macrophage differentiation. Elevated levels of CHI3L1 are associated with disorders exhibiting increased connective tissue turnover, such as rheum atoid, arthritis, osteoarthritis, scleroderma, and cirrhosis of liver, but is produced in cartilage from old donors or patiens with osteoarthritis. CHI3L1 is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular response to various environmental events that are reported to increase the risk of schizophrenia.

References

Zhao XZH, et al. (2007) Functional Variants in the Promoter Region of Chitinase 3-Like 1 (CHI3L1) and Susceptibility to Schizophrenia.The American Journal of Human Genetics. 80 (1): 12-18.Rehli M, et al. (2003) Transcriptional Regulation of CHI3L1, a Marker Gene for Late Stages of Macrophage Differentiation. The Journal of Biological Chemistry. 278: 44058-67.Nishikawa KC, et al. (2003) gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells. Experimental Cell Research. 287 (1): 79-87

NCBI and Uniprot Product Information

• NCBI GI #: 635377452
• NCBI GeneID: 12654
• UniProt Accession #: Q61362; Q3U291; Q4FJW9; Q8BKL8; Q99J84; B0FEU7; D3Z2P2
• Molecular Weight: 42,805 Da
• NCBI Official Full Name: Chitinase-3-like protein 1
• NCBI Official Synonym Full Names: chitinase-like 1
• NCBI Official Symbol: Chil1
• NCBI Official Synonym Symbols: Gp39; Brp39; Chi3l1; AW208766
• NCBI Protein Information: chitinase-3-like protein 1; GP-39; CGP-39; chitinase 3-like 1; cartilage glycoprotein 39; breast regression protein 39
• UniProt Protein Name: Chitinase-3-like protein 1
• Protein Family: Chitinase-3-like protein
• UniProt Gene Name: Chi3l1
• UniProt Synonym Gene Names: Brp39; Chil1; CGP-39; GP-39
• UniProt Entry Name: CH3L1_MOUSE

Uniprot Description

CHI3L1: Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment. A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. Belongs to the glycosyl hydrolase 18 family.

Protein type: Secreted; Secreted, signal peptide; Cell adhesion

Cellular Component: extracellular space; endoplasmic reticulum; cytoplasm; extracellular region

Molecular Function: chitin binding; chitinase activity; hydrolase activity, hydrolyzing O-glycosyl compounds

Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; apoptosis; carbohydrate metabolic process; activation of NF-kappaB-inducing kinase; immune response; chitin catabolic process; inflammatory response; lung development