NCBI and Uniprot Product Information
Uniprot Description
CHI3L1: Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment. A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. Belongs to the glycosyl hydrolase 18 family.
Protein type: Secreted; Secreted, signal peptide; Cell adhesion
Cellular Component: extracellular space; endoplasmic reticulum; cytoplasm; extracellular region
Molecular Function: chitin binding; chitinase activity; hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; apoptosis; carbohydrate metabolic process; activation of NF-kappaB-inducing kinase; immune response; chitin catabolic process; inflammatory response; lung development
Research Articles on YKL-40
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Product Notes
The Human YKL-40 chi3l1 (Catalog #AAA3800104) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA3800104 ELISA Kit recognizes Human YKL-40. It is sometimes possible for the material contained within the vial of "YKL-40, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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