Rabbit VLK Polyclonal Antibody | anti-VLK antibody

VLK Antibody

Cat. Num. AAA9403086

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: VLK; Polyclonal Antibody; VLK Antibody; Vertebrate lonesome kinase; protein kinase domain containing cytoplasmic homolog; PKDCC; SGK439; anti-VLK antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 492

• Applicable Applications for anti-VLK antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 15 amino acid peptide from near the center of human VLK.
• Target Name: VLK
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of VLK in human lung tissue lysate with VLK antibody at 1 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of VLK in rat lung tissue with VLK antibody at 2.5 ug/mL.)

Related Product Information for anti-VLK antibody

VLK was identified as a novel protein kinase that was induced after the differentiation of cultured embryonic stem cells into mesendoderm. It has no homologs in invertebrates, but is highly conserved in vertebrate species although it does not belong to any known protein kinase groups. VLK is initially expressed in E-cadherin-positive anterior visceral endoderm and mesendoderm, but its expression is later confined to E-cadherin-negative mesenchyme. It is enriched in the Golgi apparatus and is thought to regulate the rate of protein export from the Golgi. Targeted disruption of VLK in mice leads to a defect in lung development and neonatal lethality. It has been suggested that mutations in VLK may be associated with the allergic condition atopy.

Product Categories/Family for anti-VLK antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 238636897
• Molecular Weight: 48,988 Da
• NCBI Official Full Name: vertebrate lonesome kinase
• UniProt Protein Name: Extracellular tyrosine-protein kinase PKDCC
• UniProt Gene Name: Pkdcc
• UniProt Entry Name: PKDCC_MOUSE

Uniprot Description

PKDCC: Protein kinase which is required for longitudinal bone growth through regulation of chondrocyte differentiation. Involved in protein transport from the Golgi apparatus to the plasma membrane. Belongs to the protein kinase superfamily.

Protein type: Protein kinase, Other; Kinase, protein; EC 2.7.10.2; Other group; SgK493 family

Cellular Component: Golgi apparatus; extracellular region

Molecular Function: transferase activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; kinase activity; ATP binding; protein kinase activity

Biological Process: ossification; peptidyl-tyrosine phosphorylation; multicellular organismal development; negative regulation of Golgi to plasma membrane protein transport; multicellular organism growth; palate development; positive regulation of bone mineralization; protein amino acid phosphorylation; limb morphogenesis; bone mineralization; protein transport; positive regulation of chondrocyte differentiation; transport; cell differentiation; phosphorylation; alveolus development; skeletal development; embryonic gut development