Rabbit TIMP2 Polyclonal Antibody | anti-Timp2 antibody
TIMP2 (Metalloproteinase Inhibitor 2, CSC-21K, Tissue Inhibitor of Metalloproteinases 2, TIMP-2)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: Western Blot:1-2ug/ml
NCBI and Uniprot Product Information
NCBI Description
acts as an inhibitor of metallopeptidase activity; may play a role in tissue remodeling during spermatogenesis [RGD]
Uniprot Description
TIMP2: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Interacts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. Down-regulated by TGFB1. Belongs to the protease inhibitor I35 (TIMP) family.
Protein type: Secreted; Cell development/differentiation; Secreted, signal peptide; Inhibitor; Motility/polarity/chemotaxis; Extracellular matrix
Cellular Component: extracellular space; proteinaceous extracellular matrix; neuron projection; growth cone; cell surface; cell soma; basement membrane; nucleus
Molecular Function: integrin binding; metalloendopeptidase inhibitor activity; protease binding; metal ion binding; enzyme activator activity
Biological Process: negative regulation of proteolysis; regulation of Rap protein signal transduction; response to drug; positive regulation of catalytic activity; negative regulation of metalloenzyme activity; central nervous system development; regulation of neuron differentiation; regulation of cAMP metabolic process; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; response to cytokine stimulus; regulation of MAPKKK cascade; negative regulation of Ras protein signal transduction; negative regulation of mitotic cell cycle; spermatogenesis; positive regulation of adenylate cyclase activity; positive regulation of neuron differentiation; aging
Research Articles on Timp2
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Product Notes
The Timp2 timp2 (Catalog #AAA628056) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TIMP2 (Metalloproteinase Inhibitor 2, CSC-21K, Tissue Inhibitor of Metalloproteinases 2, TIMP-2) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TIMP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot:1-2ug/ml. Researchers should empirically determine the suitability of the Timp2 timp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIMP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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