Typical Testing Data/Standard Curve
Mouse TIMP2 ELISA Kit | TIMP2 elisa kit
Mouse TIMP2 ELISA Kit
Typical Testing Data/Standard Curve
Typical Testing Data/Standard Curve
Background/Introduction: TIMP2 gen is encoded by 5 exons spanning 83 kb of genomic DNA. TIMP2 is 83 kilobase pairs (kb) long with exon-intron splicing sites located in preserved positions among the three members of the TIMP family. The gene for tissue inhibitor of metalloproteinases-2 is localized on human chromosome arm 17q25. TIMP2 abrogates angiogenic factor-induced endothelial cell proliferation in vitro and angiogenesis in vivo independent of MMP inhibition. The standard product used in this kit is recombinant human TIMP2 with the molecular mass of 22Kda and 194 amino acid.
NCBI and Uniprot Product Information
Uniprot Description
TIMP2: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Interacts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. Down-regulated by TGFB1. Belongs to the protease inhibitor I35 (TIMP) family.
Protein type: Secreted; Cell development/differentiation; Extracellular matrix; Motility/polarity/chemotaxis; Inhibitor; Secreted, signal peptide
Cellular Component: basement membrane; cell soma; cell surface; extracellular region; extracellular space; growth cone; neuron projection
Molecular Function: enzyme activator activity; enzyme inhibitor activity; integrin binding; metal ion binding; metalloendopeptidase inhibitor activity; protease binding; protease inhibitor activity
Biological Process: negative regulation of cell proliferation; negative regulation of membrane protein ectodomain proteolysis; negative regulation of metalloenzyme activity; negative regulation of mitotic cell cycle; negative regulation of peptidase activity; negative regulation of proteolysis; negative regulation of Ras protein signal transduction; positive regulation of adenylate cyclase activity; positive regulation of MAPKKK cascade; positive regulation of neuron differentiation; regulation of cAMP metabolic process; regulation of MAPKKK cascade; regulation of neuron differentiation; regulation of Rap protein signal transduction; response to cytokine stimulus; response to hormone stimulus
Research Articles on TIMP2
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Product Notes
The Mouse TIMP2 timp2 (Catalog #AAA8244600) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA8244600 ELISA Kit recognizes Mouse TIMP2. AAA Biotech's TIMP2 can be used in a range of immunoassay formats including, but not limited to, Sandwich ELISA (EIA). Researchers should empirically determine the suitability of the TIMP2 timp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIMP2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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