Target Description: The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants.
NCBI and Uniprot Product Information
NCBI Description
The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Description
STX3: Potentially involved in docking of synaptic vesicles at presynaptic active zones. Belongs to the syntaxin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q12.1
Cellular Component: SNARE complex; synaptic vesicle; specific granule; azurophil granule; neuron projection; growth cone; lamellipodium; apical plasma membrane; dendrite; plasma membrane; integral to membrane; vacuole; intercellular junction
Molecular Function: arachidonic acid binding; SNAP receptor activity; protein binding; SNARE binding
Biological Process: synaptic vesicle fusion to presynaptic membrane; intracellular protein transport; vesicle docking; positive regulation of cell adhesion; positive regulation of chemotaxis; positive regulation of cell proliferation; neurite development
Research Articles on STX3
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Product Notes
The STX3 stx3 (Catalog #AAA3214381) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The STX3 Antibody - middle region reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's STX3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the STX3 stx3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: VRNKLKSMEK HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD. It is sometimes possible for the material contained within the vial of "STX3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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